Salivary Redox Biomarkers in Relation to Oral Health Condition Among a Group of Ionizing Radiation Field Workers
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 主要终点
- oral health status
研究概览
简要总结
The goal of this study is to test the effect of ionizing radiation on salivary Redox status among a group of ionizing radiation workers by measuring salivary biomarkers(malondialdehyde,8_hydroxy_deoxyguanosine and catalase) and measuring oral health condition by plaque index.
90 male subjects will be enrolled in this study between 30_40 years old worked in Baghdad teaching hospital ,30 subjects exposed from computed tomography department ,30 subjects exposed from x_ray department and 30 subjects unexposed from laboratory department in the same hospitals.
The method of the study is taking unstimulated saliva sample from the subjects and oral health measure.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 30 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •male, 30_40 years ,no history of systemic disease, no medical treatment taken at least 3 months before sampling and the subjects are exposed to radiation 5_ 10 years
排除标准
- •subjects with medical history , subjects are taken medications during last 3 months , the subjects are exposed to radiation less than 5 years or more than 10 years
结局指标
主要结局
oral health status
时间窗: Baseline: the subjects must be fasting. up to two hours saliva collection
Changes in the clinical periodontal parameter (Plaque index ) To determine the patients' plaque index, their dental plaque thickness was evaluated by probing the mesial, distal, buccal, and palatal surfaces of all teeth using a Williams periodontal probe. The individual's plaque index was determined by summing the values obtained for each tooth and calculating the averages.Silness \& Löe (Silness \& Löe,1964) reference values were taken as a basis The Plaque Index (PI) scores each site on a 0 to 3 scale Score 0 : No plaque is in the area adjacent to the gingiva. Score 1: There is a plaque in the form of a thin film on the gingival margin. Score 2: There is a visible plaque in the gingival pocket and gingival margin. Score 3: There is a dense plaque in the gingival pocket and on the gingival margin.
次要结局
- Salivary Malondialdehyde biomarker(Baseline:saliva collection for malondialdehyde . up to two hours fasting for all subjects.)
- Salivary 8_ hydroxy_deoxyguanosine biomarker(Baseline:saliva collection for 8_hydroxy_deoxyguanosine .up to two hours fasting for all subjects.)
- Salivary catalase biomarker(Baseline:saliva collection for catalase . up to two hours fasting for all subjects.)
研究者
Jihan munther hussien
Master student
Al-Mustansiriyah University