Heat Shock Proteins: a Pathogenic Driver and Potential Therapeutic Target in Acute Pancreatitis
试验速览
- 阶段
- 不适用
- 入组人数
- 280
- 试验地点
- 1
- 主要终点
- To measure the levels of heat shock proteins in serum and plasma in acute severe pancreatitis settings
研究概览
简要总结
To investigate the role of Heat Shock Proteins in the mechanism of acute severe pancreatitis. In addition to test the potential treatment target of acute pancreatitis.
All patients who present with clinical symptoms of acute pancreatitis are evaluated for the enrollment of the study.
详细描述
All patients with acute pancreatitis are evaluated according to modified Atlanta classification acute pancreatitis severity scores.
Blood serum, urine and DNA samples are collected from all patients presented on admission, after 24 hours, 48 hours, 72 hours.
CT is performed in al patients to evaluate necrosis of pancreas Day 5-7 since hospital admission. If necrosis is not present follow-up is stopped.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •no prior diagnosis of acute pancreatitis
- •admission to the hospital within 2 days since the clinical symptoms
- •confirmed diagnosis of acute pancreatitis
排除标准
- •chronic pancreatitis
- •pancreatic cancer
结局指标
主要结局
To measure the levels of heat shock proteins in serum and plasma in acute severe pancreatitis settings
时间窗: 2 years
Different molecular weight Heat Shock proteins role while developing acute pancreatitis.
次要结局
- To measure pancreas cells activity while applying Heat Shock Protein inhibitors(2 years)
研究者
Aiste Gulla
Senior surgery resident
Vilnius University