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临床试验/NCT03634787
NCT03634787Unknown不适用

Heat Shock Proteins: a Pathogenic Driver and Potential Therapeutic Target in Acute Pancreatitis

Vilnius University1 个研究点 分布在 1 个国家目标入组 280 人开始时间: 2017年10月20日最近更新:
适应症

试验速览

阶段
不适用
入组人数
280
试验地点
1
主要终点
To measure the levels of heat shock proteins in serum and plasma in acute severe pancreatitis settings

研究概览

简要总结

To investigate the role of Heat Shock Proteins in the mechanism of acute severe pancreatitis. In addition to test the potential treatment target of acute pancreatitis.

All patients who present with clinical symptoms of acute pancreatitis are evaluated for the enrollment of the study.

详细描述

All patients with acute pancreatitis are evaluated according to modified Atlanta classification acute pancreatitis severity scores.

Blood serum, urine and DNA samples are collected from all patients presented on admission, after 24 hours, 48 hours, 72 hours.

CT is performed in al patients to evaluate necrosis of pancreas Day 5-7 since hospital admission. If necrosis is not present follow-up is stopped.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
18 Years 至 100 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • no prior diagnosis of acute pancreatitis
  • admission to the hospital within 2 days since the clinical symptoms
  • confirmed diagnosis of acute pancreatitis

排除标准

  • chronic pancreatitis
  • pancreatic cancer

结局指标

主要结局

To measure the levels of heat shock proteins in serum and plasma in acute severe pancreatitis settings

时间窗: 2 years

Different molecular weight Heat Shock proteins role while developing acute pancreatitis.

次要结局

  • To measure pancreas cells activity while applying Heat Shock Protein inhibitors(2 years)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Aiste Gulla

Senior surgery resident

Vilnius University

研究点 (1)

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