Cardiac complications of diabetic ketoacidosis (DKA) in children and adolescents

Recruiting

Conditions: Diabetes mellitus typ 1 with and without ketoacidose

Registration Number: DRKS00032719

Lead Sponsor: Kinder- und Jugendkrankenhaus AUF DER BULT

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 90

Inclusion Criteria

Manifestation of type 1 diabetes
- Age 0 - 17 years
- Written consent from at least one parent/legal guardian

Exclusion Criteria

- Known heart defects such as hemodynamically relevant ventricular or atrial septal defect, transposition of the great arteries, aortic isthmus stenosis, tetralogy of Fallot, hypoplastic left heart syndrome, Ebstein anomaly, double aortic arch
- Pre-existing heart failure
- Known arterial hypertension
- Known renal insufficiency
- Chronic pulmonary diseases: severe bronchial asthma, cystic fibrosis, pulmonary hypertension
- Cancers with a history of chemotherapy
- Pregnancy (clinical indication)

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of pathologically elevated cardiac biomarkers and their correlation with functional abnormalities in DKA

Secondary Outcome Measures

Name	Time	Method
- Influence of the pH value on the increase in troponin I<br>- Evaluation of the volume administered on NT-proBP elevation<br>- Influence of the administered volume on echocardiographically proven contractility disorders<br>- Evaluation of different troponin elevation between the sexes