Augmentation of Working Memory Training With Transcranial Direct Current Stimulation (tDCS) in Patients With Schizophrenia
Not Applicable
Recruiting
- Conditions
- Cognitive DeficitsF20.0Paranoid schizophrenia
- Registration Number
- DRKS00018764
- Lead Sponsor
- niversity Hospital Tuebingen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 66
Inclusion Criteria
diagnosis of schizophrenia or schizoaffective disorder
- age 18-60 years
- Ability to give informed consent
- right handedness
- stable antipsychotic medication one week prior to the experiment and during the training sessions
Exclusion Criteria
- epilepsy
- metal implants near the head
- pregnancy
- use of antiepileptics
- use of benzodiazepines > 1 mg lorazepam equivalent
- current substance abuse (excluding tabacco)
- missing consent of the legal representative, if existing
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Change (post training - pre training) in working memory task performance (1-, 2-, 3-back).; time frame: Pre Training: 3-4 days before training start. Post Training: 3-4 days after completion of working memory training.; Use of d' and response time as dependent variables. Based on signal detection theory, the discriminability index d' (d-prime) is calculated by using the formula d' = Z(hit rate) - Z(false alarm rate).
- Secondary Outcome Measures
Name Time Method