Radial Artery Versus Saphenous Vein Patency (RSVP) Trial - 10 Year Follow-up

Not Applicable

Withdrawn

• Conditions: Coronary Artery Disease
• Interventions: Procedure: Coronary artery bypass surgery using a long saphenous vein conduit; Procedure: Coronary artery bypass (CABG) surgery using a radial arterial conduit

• Registration Number: NCT01622387
• Lead Sponsor: Imperial College London

Brief Summary

During coronary bypass surgery, veins are taken from the leg and applied to the heart and aorta to 'bypass' narrowings in the coronary arteries. However using an artery in the chest, the internal mammary artery, means that the bypass lasts longer than using veins. The investigators recently showed that using an artery from the arm as a bypass vessel, the radial artery, also had less furring up than veins 5 years after surgery. Now the investigators would like to ask patients to come back for an angiogram 10 years following surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-10-13
• Study First Submitted: 2012-03-22
• Study First Submitted QC: 2012-06-14
• Study First Posted: 2012-06-19
• Primary Completion: 2014-07-03
• Study Completion: 2014-07-03
• Status Verified: 2015-08
• Last Update Submitted: 2019-02-27
• Last Update Posted: 2019-03-01

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Included in the RSVP study
• Willing to attend for coronary angiography
• Willing to give written informed consent

Exclusion Criteria

• Contraindication to coronary angiography
• participation in research project within previous 60 days
• unwilling to give written informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Long saphenous vein	Coronary artery bypass surgery using a long saphenous vein conduit	Use of long saphenous vein as a conduit in CABG surgery
Radial artery	Coronary artery bypass (CABG) surgery using a radial arterial conduit	Use of the radial artery as a conduit in CABG surgery

Primary Outcome Measures

Name	Time	Method
Proportion of radial artery and saphenous vein grafts patent at 10 years	10 years post surgery	Comparison of the patency of radial artery and long saphenous aorto-coronary bypass grafts at 10 years, assessed by an independent observer

Secondary Outcome Measures

Name	Time	Method
Patency (patent or complete occlusion, and secondary visual grading) of radial artery and internal mammary artery coronary bypass grafts	10 years post surgery	Compare the patency (patent or complete occlusion, and secondary visual grading) of radial artery and internal mammary artery coronary bypass grafts
Angiographic visual grading	10 years post surgery	Compare secondary angiographic visual grading in radial artery and long saphenous vein grafts

Trial Locations

Locations (1)

Royal Brompton & Harefield NHS Foundation Trust; 🇬🇧 London, United Kingdom