Elevated Platelet Count as Prognostic Factor in Colorectal Cancer With Synchronous Liver Metastases: a Retrospective Single-center Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 196
- 试验地点
- 1
- 主要终点
- Overall survival
研究概览
简要总结
Colorectal cancer (CRC) is the third most common malignancy worldwide and is often metastatic at diagnosis. Despite progresses in surgical techniques and the introduction of novel chemotherapy regimens, many patients still suffer from a poor prognosis. It is therefore of utmost importance to identify prognostic markers that may improve selection of patients.
In recent years several studies demonstrated that preoperative blood tests as platelet count or neuthophil-to-lymphocyte ratio could be prognostic factors in CRC as well as other malignancies. The aim of this study was to evaluate the role of preoperative platelet count (PC) in patients with synchronous colorectal liver metastases.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Colorectal cancer with synchronous liver metastases
- •Possibility to retrieve pre-operative platelet count
- •Age of 18 years or older
- •Availabilty of clinical-pathological data
- •Minimum follow up of 12 months
排除标准
- 未提供
结局指标
主要结局
Overall survival
时间窗: 5 years
correlation between high PC and overall survival
次要结局
- Clinic-pathological variables(30 days)
研究者
Corrado Pedrazzani
Principal Investigator
Azienda Ospedaliera Universitaria Integrata Verona