Extubation in the Operating Room After Living Donor Liver Transplantation in Adult Patients: a Retrospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 277
- 试验地点
- 1
- 主要终点
- length of intensive care unit stay
研究概览
简要总结
Duration of mechanical ventilation, length of intensive care unit stay, length of postoperative hospital stay, and the incidence rates of complications between the group with endotracheal tube extubation in the operating room (OR-EX) and those without (NOR-EX) in patients who underwent living-donor liver transplantation for end-stage liver failure are going to be compared. Through these results, it is investigated whether endotracheal tube extubation in the operating room is useful in reducing the length of stay in the intensive care unit and the hospital stay after surgery in patients who have undergone living-donor liver transplantation.
详细描述
Long-term mechanical ventilation after liver transplantation may increase the risk of complications such as pneumonia, sepsis, and multi-organ failure. Recent advances in surgical techniques and the introduction of short-acting anesthetics have accelerated the recovery of liver transplant recipients, and early extubation after liver transplantation is being proposed as a standard method. The results of a study on early extubation in patients undergoing liver transplantation suggested a reduction in the length of stay in the neutralizer room and predictors of early extubation. However, these studies are limited to males, and there is no study in which the definition of early extubation includes extubation in the operating room or extubation in the operating room within 1-3 hours of arrival in the intensive care unit.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients 18 years of age or older who underwent living-donor liver transplantation for end-stage liver failure
排除标准
- •A score of 26 or higher on the model for end-stage liver disease (MELD) scale
- •In case of endotracheal intubation when entering the operating room
- •If hepatic encephalopathy is stage 3 or higher at the time of admission to the operating room
- •When the arterial blood partial pressure (PaO2)/inhaled oxygen fraction (FiO2) ratio is less than 200 on the Arterial Blood Gas Analysis (ABGA) before the end of the living liver transplantation operation
- •Preoperative chest X-ray examination or chest computed tomography shows pulmonary edema
- •If patients is diagnosed with hepatopulmonary syndrome before surgery
结局指标
主要结局
length of intensive care unit stay
时间窗: during intensive care unit stay, up to 3 months
length of intensive care unit stay
length of postoperative hospital stay
时间窗: during hospital stay, up to 6 months
length of postoperative hospital stay
次要结局
- incidence rates of complications(during admission, up to 6 months)
研究者
Kim Hee Young
Clinical associate professor
Pusan National University Yangsan Hospital