Breathing in Newborns: Evaluating the Impact of Salbutamol, Furosemide, and Their Combination on Newborn Breathing at CMH Peshawar's Neonatal Intensive Care Unit

Phase 3

Not yet recruiting

Conditions: Transient Tachypnea of the Newborn
Respiratory - Other respiratory disorders / diseases
Reproductive Health and Childbirth - Complications of newborn

Registration Number: ACTRN12624000987561

Lead Sponsor: Dr.Aamir Iqbal

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Not yet recruiting

Sex: All

Target Recruitment: 200

Inclusion Criteria

1.Age: Newborns (neonates) less than 48 hours old.
2.Diagnosis: Confirmed diagnosis of transient tachypnea of the newborn (TTN) based on clinical and radiological findings, including:-
-Clinical Findings: Rapid breathing (respiratory rate > 60 breaths per minute), grunting, nasal flaring, and mild to moderate retractions.-
-Radiological Findings: Chest X-ray showing prominent pulmonary vascular markings, fluid in the fissures, and/or mild overexpansion.-
3.Gestational Age: Full-term infants (37 to 42 weeks of gestation)
4.Birth Weight: Appropriate for gestational age (AGA) infants with birth weight between 2.5 kg and 4.0 kg.
5.Vital Signs: Stable cardiovascular status, defined by:
-Heart Rate: 100 to 160 beats per minute
-Blood Pressure: Systolic 60-90 mmHg, Diastolic 30-60 mmHg 6.Consent: Written informed consent obtained from parents or legal guardians.

Exclusion Criteria

1.Age:Newborns older than 48 hours.
2.Diagnosis:-Presence of congenital heart disease or other significant congenital anomalies.
-Evidence of meconium aspiration syndrome or respiratory distress syndrome.
3.Gestational Age:Preterm infants (less than 37 weeks of gestation) or post-term infants (more than 42 weeks of gestation).
4.Birth Weight:Small for gestational age (SGA) infants with birth weight below 2.5 kg or large for gestational age (LGA) infants with birth weight above 4.0 kg.
5.Vital Signs:Unstable cardiovascular status, defined by abnormal heart rate or blood pressure for age despite medical management.
-Abnormal heart rate (< 100 beats per minute or > 160 beats per minute).
-Abnormal blood pressure (Systolic < 60 mmHg or > 90 mmHg, Diastolic < 30 mmHg or > 60 mmHg).
6.Medical History:
-History of maternal drug use during pregnancy known to affect respiratory function (e.g., beta-blockers, narcotics).
-History of birth asphyxia or perinatal hypoxia.Informed 7.Consent:Lack of written informed consent from parents or legal guardians.