Prevention of Anthracycline-induced Cardiotoxicity

Phase 3

Active, not recruiting

• Conditions: Cancer
• Interventions: Drug: Enalapril

• Registration Number: NCT01968200
• Lead Sponsor: European Institute of Oncology

Brief Summary

Anthracycline based anti-tumoral therapies are know to develop cardiac damage that could also lead to heart failure. Monocentric studies proved that a treatment with ACE inhibitors (ACEi) and betablockers (BB) during the first elevation of cardiac troponin is able to reduce the incidence of heart failure (HF).

ICOS-ONE trial is a multicenter randomized trial comparing two therapeutic strategies. The main objective is to assess whether enalapril started concomitantly to AC-containing treatments, can prevent cardiac toxicity more effectively than when enalapril is prescribed to selected patients showing laboratory evidences of injury after chemotherapy, during follow-up visits in 268 patients.

Detailed Description

Anthracycline-containing chemotherapy is well known to cause dose-dependent, progressive cardiac damage in particular left ventricular dysfunction evolving to heart failure. The development of cardiac dysfunction, even asymptomatic, leads to the exclusion of cancer patients from effective chemotherapy, with a possible negative impact on their oncologic prognosis. The use of troponins (cTn) during cancer chemotherapy with anthracyclines (AC) allows to identify early cardiac injury before the onset of left ventricular dysfunction, with high predictive value. ACE inhibitors (ACEi) and betablockers (BB) prescribed to cancer patients when, during the course or after the end of a chemotherapy, signs or symptoms of cardiac failure are detected, have been shown to be protective in monocentric studies. Prophylaxis with an ACEi, enalapril and a BB, bisoprolol in patients treated with AC-chemotherapy may allow to reduce the risk of cardiovascular injury, allowing for the completion of the whole scheduled antitumoral treatment.

Sample size According to previous studies from the European Institute of Oncology IEO), an increase of circulating troponin levels is estimated to be 20% in the patients treated with anthracyclines at conventional dosage. 134 patients in each arm (Total sample size of 268 patients) are required to detect a 50% relative risk reduction in the incidence of elevated troponins levels at a 2-sided alpha=0.05 and a 1-beta=0.60, taking into account a 5% drop-out rate. This endpoint will allow to compare the strategy based on prevention (arm 1) with the strategy guided by troponin (arm 2). Given the originality of the proposal and the limited resources, this study will be exploratory in nature, waiting for a larger and adequately powered clinical trial designed to observe significant differences in clinical events.

Safety Tolerability of enalapril, valsartan and bisoprolol has been proven over several years and in broad populations of cardiac patients, not only with heart failure, but also at cardiovascular risk in the absence of signs or symptoms of HF. Specific unwanted effects in cancer patients are not expected, based on previous experiences. Special care should be taken to avoid profound hypotension induced by enalapril, valsartan and bisoprolol in these patients. Serious Adverse Events (SAEs) ad Suspected and Unsuspected Serious Adverse Reactions (SUSARs) will be collected and treated appropriately.

Study Timeline

• Study Start: 2012-12
• Study First Submitted: 2013-07-29
• Study First Submitted QC: 2013-10-18
• Study First Posted: 2013-10-23
• Primary Completion: 2019-12
• Status Verified: 2023-06
• Last Update Submitted: 2023-06-27
• Last Update Posted: 2023-06-28
• Study Completion: 2023-12

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 268

Inclusion Criteria

1. Patients with diagnosis of cancer and indication for first- and second-line therapy with anthracyclines
2. Age ≥18years
3. Serum creatinine<177µmol/L(2mg/100mL)
4. Systolic blood pressure ≥100 mmHg and ≤170 mmHg
5. Left ventricular ejection fraction (VEF) >50%
6. Written informed consent.
7. Life expectancy of at least 12 months

Exclusion Criteria

1. Patients with history or clinical/instrumental evidences of heart failure
2. Patients with history or clinical/instrumental evidences of ischemic heart disease;
3. Patients with blood troponin levels higher than the cut-off suggested by the manufacturer before starting cancer CT;
4. Systolic blood pressure<100 mmHg;
5. Heart rate<50 bpm;
6. Prior malignancy requiring potentially cardiotoxic chemotherapy (e.g. anthracyclines, trastuzumab..);;
7. Uncontrolled hypertension defined as systolic blood pressure>170 mmHg;
8. Treatment with ACEi, ARB or BB within 4 weeks prior to study start;
9. Known intolerance to enalapril, except for cough;
10. Planned treatment with dexrazoxane;
11. Participation in another experimental drug trial within 4 weeks prior to study start;
12. Non-cooperative behaviour or suspected poor compliance;
13. Psychiatric disorders or conditions that might impair the ability to give informed consent;
14. Pregnancy or breast feeding;
15. Scheduled mediastinal radiotherapy.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Enalapril after injury	Enalapril	Enalapril prescribed to selected patients showing laboratory evidences of injury after chemotherapy at follow-up visits.
Enalapril concomitant	Enalapril	Enalapril started concomitantly to AC-containing treatments

Primary Outcome Measures

Name	Time	Method
the occurrence of cTn elevation above the threshold in use at the local laboratory, at any time during the study	up to 1 year after the completion of the anthracyclines containing chemotherapy.	To assess whether enalapril administered concomitantly to anthracyclines (AC) containing treatments can prevent cardiac toxicity more effectively than enalapril prescribed to selected patients showing laboratory evidences of injury after chemotherapy (CT), at follow-up visits.; Cardiac toxicity is measured on the basis of cardiac troponin levels.

Secondary Outcome Measures

Name	Time	Method
admissions to hospital for cardiovascular causes,	up to 3 years after the completion of the anthracyclines containing chemotherapy.	to assess whether enalapril administered concomitantly to AC-containing treatments can reduce admissions to hospital for cardiovascular causes
occurrence of hypo- or hyperkinetic arrhythmias	up to 1 year after the completion of the anthracyclines containing chemotherapy.	to assess whether enalapril administered concomitantly to AC-containing treatments can reduce new occurrence of hypo- or hyperkinetic arrhythmias
cardiovascular deaths	up to 1 year after the completion of the anthracyclines containing chemotherapy.	to assess whether enalapril administered concomitantly to AC-containing treatments can reduce cardiovascular deaths

Trial Locations

Locations (1)

European Institute of Oncology; 🇮🇹 Milan, Italy