Splenic Artery Ligation and Portocaval Shunt in Small-for-size Syndrome

Completed

• Conditions: Liver Regeneration; Reperfusion Injury; Hepatectomy; Small-For-Size Liver Syndrome; Ligation; Splenic Artery; Portal Vein; Ischemia

• Registration Number: NCT05459883
• Lead Sponsor: Aretaieion University Hospital

Brief Summary

Our study aimed at assessing the changes of portal vein pressure, portal vein flow and hepatic arterial flow (HAF) in liver remnants ≤ 30% of the standard liver volume by reducing portal vein overflow via ligation of the splenic artery.

Detailed Description

It has been reported that prevention of acute portal overpressure in small-for-size liver grafts leads to better postoperative outcomes. Accordingly, we aimed to investigate the feasibility of the technique of splenic artery ligation in a case series of patients subjected to major liver resections with evidence of small-for-size syndrome and whether the maneuver results in reduction of portal venous pressure and flow.

Study Timeline

• Study Start: 2017-01-01
• Primary Completion: 2021-12-31
• Study Completion: 2021-12-31
• Status Verified: 2022-07
• Study First Submitted: 2022-07-10
• Study First Submitted QC: 2022-07-12
• Last Update Submitted: 2022-07-12
• Study First Posted: 2022-07-15
• Last Update Posted: 2022-07-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

• Adult patients
• American Society of Anesthesiologists (ASA) distribution I to III
• Patients scheduled for major liver resection (≥4 segments)

Exclusion Criteria

• patients with extrahepatic disease
• patients with metastatic liver tumors

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
portal vein flow	through the operation, an average period of two hours	change of portal vein flow from before liver resection to after reperfusion of the liver remnant
hepatic artery flow	through the operation, an average period of two hours	change of hepatic artery flow from before liver resection to after reperfusion of the liver remnant
portal vein pressure	through the operation, an average period of two hours	change of portal vein pressure from before liver resection to after reperfusion of the liver remnant

Trial Locations

Locations (1)

Aretaieion University Hospital; 🇬🇷 Athens, Αττική, Greece