跳至主要内容
临床试验/NCT05246176
NCT05246176Unknown不适用

Role of Ultrasonography as a Single Tool for Guidance of Percutaneous Transhepatic Biliary Drainage in Obstructive Jaundice

Sohag University1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2021年7月15日最近更新:
适应症

试验速览

阶段
不适用
入组人数
50
试验地点
1
主要终点
Correction of hyperbilirubinemia.

研究概览

简要总结

Obstructive jaundice may be of malignant and benign etiologies. Carcinoma of the gall bladder, cholangiocarcinoma, pancreatic adenocarcinoma, metastasis, and lymph nodal compression of common bile duct (CBD) constitute the majority of malignant causes.

Most of the patients with malignant obstructive jaundice are already advanced and inoperable by the time they are diagnosed, hence carry bad prognosis with palliation being the only option left. Obstruction needs to be drained even in such cases for reducing pain, cholangitis, anorexia and pruritus as well as to reduce the serum bilirubin levels in certain cases to initiate chemo or intrabiliary brachytherapy.

Over the years, palliation has evolved with the introduction of newer methods and improvisation of existing techniques. Recent palliative measures prolong longevity and improve the quality of life, hence increasing the acceptance to such procedures; Methods of biliary drainage include: a. Surgical bypass b. Minimally invasive procedures; Endoscopic retrograde (ERCP) (cholangiopancreatography (ERCP), and Percutaneous transhepatic biliary drainage (PTBD).

ERCP as well as PTBD are well-established and effective means for biliary drainage as palliative treatment in unresectable cases.

With the current modern technique in experienced hands, Percutaneous Transhepatic Biliary Drainage (PTBD) equals endoscopic retrograde cholangio pancreatography (ERCP) regarding technical success and complications. In addition, there is a reduction in immediate procedure-related mortality with proven survival benefit. Moreover, it is the only immediate lifesaving procedure in cholangitis and sepsis.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Other
盲法
None

入排标准

年龄范围
18 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Any adult Patients with malignant obstructive jaundice will included in this study

排除标准

  • Patients with bleeding diathesis.
  • Patients with associating comorbidities.
  • Patients with insufficient intrahepatic biliary dilatation < 0.5 cm or with extensive tumor infiltrates.

结局指标

主要结局

Correction of hyperbilirubinemia.

时间窗: 4 weeks

We correct hyperbilirubinemia in patient with malignant obstructive jaundice using ultrasound to insert external drain.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Mostafa Aboelmakarem Ahmed

Principal investigator

Sohag University

研究点 (1)

Loading locations...

相似试验