Ultrasonography as a Single Tool for Guided Percutaneous Transhepatic Biliary Drainage in Obstructive Jaundice
- Conditions
- Obstructive Jaundice
- Interventions
- Device: nephrostomy set
- Registration Number
- NCT05246176
- Lead Sponsor
- Sohag University
- Brief Summary
Obstructive jaundice may be of malignant and benign etiologies. Carcinoma of the gall bladder, cholangiocarcinoma, pancreatic adenocarcinoma, metastasis, and lymph nodal compression of common bile duct (CBD) constitute the majority of malignant causes.
Most of the patients with malignant obstructive jaundice are already advanced and inoperable by the time they are diagnosed, hence carry bad prognosis with palliation being the only option left. Obstruction needs to be drained even in such cases for reducing pain, cholangitis, anorexia and pruritus as well as to reduce the serum bilirubin levels in certain cases to initiate chemo or intrabiliary brachytherapy.
Over the years, palliation has evolved with the introduction of newer methods and improvisation of existing techniques. Recent palliative measures prolong longevity and improve the quality of life, hence increasing the acceptance to such procedures; Methods of biliary drainage include: a. Surgical bypass b. Minimally invasive procedures; Endoscopic retrograde (ERCP) (cholangiopancreatography (ERCP), and Percutaneous transhepatic biliary drainage (PTBD).
ERCP as well as PTBD are well-established and effective means for biliary drainage as palliative treatment in unresectable cases.
With the current modern technique in experienced hands, Percutaneous Transhepatic Biliary Drainage (PTBD) equals endoscopic retrograde cholangio pancreatography (ERCP) regarding technical success and complications. In addition, there is a reduction in immediate procedure-related mortality with proven survival benefit. Moreover, it is the only immediate lifesaving procedure in cholangitis and sepsis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
- Any adult Patients with malignant obstructive jaundice will included in this study
- Patients with bleeding diathesis.
- Patients with associating comorbidities.
- Patients with insufficient intrahepatic biliary dilatation < 0.5 cm or with extensive tumor infiltrates.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Cases nephrostomy set group of patient with inoperable malignant obstructive jaundice with failed internal drainage.
- Primary Outcome Measures
Name Time Method Correction of hyperbilirubinemia. 4 weeks We correct hyperbilirubinemia in patient with malignant obstructive jaundice using ultrasound to insert external drain.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Sohag University Hospital
🇪🇬Sohag, Egypt