Public health targeting of PrEP at HIV positives’ bridging networks

Hellenic Scientific Society for the Study of AIDS and Sexually Transmitted Diseases0 个研究点目标入组 100 人开始时间: 2017年3月29日最近更新: 2019年12月10日

试验速览

暂无简介。

•1. Born to male gender, age 18 years or more.
•2. Documented negative HIV antibody test(s) immediately before starting PrEP medication (up until 3 days before commencement of therapy).
•3. Completed screen for STIs (syphilis, gonorrhoea, chlamydia).
•4. Confirm that the patient is at substantial, ongoing, high risk for acquiring HIV infection in the past 6 months:
•oPatients with sexual (MSM, MSMTF) or intravenous drug use risks for acquiring HIV should be considered for starting the PrEP medication.
•Sexual risk includes (1) condomless anal sex with =2 male or transgender female partners; (2) =2 episodes of anal sex with at least 1 HIV-infected partner; or (3) sex with a male or transgender female partner and self-reported history of syphilis, rectal gonorrhoea, or rectal chlamydia.
•5. Confirm that the patient’s” calculated creatinine clearance is greater than or equal to 60 mL/minute (via Cockcroft-Gault formula).
•6. Willing and able to provide written informed consent.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•1. An acute viral illness that could be due to a primary HIV infection syndrome.
•2. Any contraindications to Truvada® according to the current package insert.
•3. Treatment for hepatitis B infection, ongoing or programmed.
•4. Administration (current or expected) of a treatment that may be toxic to the kidneys (long-term anti-inflammatory use).
•5. Serious disease which could require a treatment that could disrupt the compliance to PrEP.
•6. Participation in other interventional clinical trials 30 days prior to enrolment in the present clinical study.
•7. Inability or unwillingness to comply to study protocol requirement adjunct to primary objectives.

发起方

Hellenic Scientific Society for the Study of AIDS and Sexually Transmitted Diseases