Pacing Away From Heart Failure: Left bundle branch area pacing or biventricular pacing in patients with atrial fibrillation and left ventricular dysfunctio

Phase 3

• Conditions: cardiac pump failure; Heart failure; 10019280

• Registration Number: NL-OMON56990
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 9 September 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 17

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all
of the following criteria:
- Adults >=18 years with permanent AF and LVEF < 50% who either require
ventricular pacing because of bradycardia including patients undergoing AV
junction ablation, or have an indication for cardiac resynchronization therapy.
- Expected percentage of ventricular pacing > 40%
- >= 3 months of heart failure medication optimization

Of note, patients who already have a device, but require an upgrade to a
cardiac resynchronization therapy device, can also be included

Exclusion Criteria

- Age < 18 years
- Pregnancy or active pregnancy wish
- Not eligible for implantation of an RV lead, LBBAP lead, or LV lead in the
coronary sinus
- The need for a right-sided device implantation
- Recent valve intervention/surgery or acute myocardial infarction (< 6 months)
- NYHA functional class IV heart failure, left ventricular assist device or
cardiac transplant

Study & Design

• Study Type: Interventional
• Study Design: Not specified