Evaluation of Blood Biomarkers as an Indicator of Postoperative Cognitive Dysfunction

Not Applicable

• Conditions: Postoperative Cognitive Dysfunction
• Interventions: Diagnostic Test: Blood sampling for assessment of the level of D-Amino Acid Oxidase, D-serine and Serine in blood; Diagnostic Test: Neurocognitive test; Diagnostic Test: Assessment of delirium

• Registration Number: NCT04679259
• Lead Sponsor: SMG-SNU Boramae Medical Center

Brief Summary

Postoperative cognitive dysfunction is defined as a cognitive decline arising after surgery. In the present study, the authors evaluate the level of D-Amino Acid Oxidase, D-serine and Serine in blood as an indicator of postoperative cognitive dysfunction after cardiac surgery.

Detailed Description

Not available

Study Timeline

• Status Verified: 2020-12
• Study First Submitted: 2020-12-11
• Study Start: 2020-12-21
• Study First Submitted QC: 2020-12-21
• Last Update Submitted: 2020-12-21
• Study First Posted: 2020-12-22
• Last Update Posted: 2020-12-22
• Primary Completion: 2022-12-30
• Study Completion: 2023-01-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 149

Inclusion Criteria

• Patients scheduled for elective cardiac surgery

Exclusion Criteria

• MMSE <24
• History of psychological or neurological diseases
• Illiteracy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Cardiac surgical patients	Neurocognitive test	-
Cardiac surgical patients	Blood sampling for assessment of the level of D-Amino Acid Oxidase, D-serine and Serine in blood	-
Cardiac surgical patients	Assessment of delirium	-

Primary Outcome Measures

Name	Time	Method
Change of concentration of D-Amino Acid Oxidase in blood at 1, 2, and 7 day after surgery	At 1, 2, and 7 day after surgery	Blood level of D-Amino Acid Oxidase is assessed.

Secondary Outcome Measures

Name	Time	Method
Concentration of D-serine in blood	At 1, 2, and 7 day after surgery	Blood level of D-serine is assessed.
Concentration of Serine in blood	At 1, 2, and 7 day after surgery	Blood level of Serine is assessed.
The incidence of postoperative delirium	Daily for 7 days after surgery	The incidence of postoperative delirium is evaluated.
The incidence of postoperative cognitive dysfunction	At 7 day after surgery	The occurrence of postoperative cognitive dysfunction is evaluated at 7 day after surgery