Cognitive Function After Radiation Therapy for Primary Brain Tumours
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Primary Brain Tumour
- Sponsor
- University of Aarhus
- Enrollment
- 300
- Locations
- 5
- Primary Endpoint
- Impairment of verbal learning and memory as assessed by the HVLT-r test
- Status
- Recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
This study will assess cognitive function in patients with a primary brain tumour treated with radiation therapy (RT) to generate radio-sensitivity and volume effect parameters for the development of cognitive dysfunction. All types of brain tumours apart from glioblastoma will be included.
Detailed Description
RT is fundamental in the treatment of primary brain tumours. RT contributes to improved local control and prolonged progression-free survival in patients with a broad range of tumour types. Irradiation to the normal brain may lead to cognitive impairments. Clarifying the nature and severity of impairment in adult RT-treated brain tumour patients, including region-specific effects, are important for optimal utilization of novel conformal RT technologies such as proton therapy. The study is a prospective nationwide study including approximately 300 brain tumour patients from the Danish Center of Particle Therapy and the four Neuro Oncology Centers in Denmark. The patients will be assessed with a comprehensive battery of standardized cognitive tests and complete a questionnaire (PRO's). They will do this prior to RT treatment and 1, 3, 5 and 10 years afterwards. The PRO's includes measures on quality of life, fatigue, sleep, depression, anxiety, and socio demographics. The standardized tests are: Trail making Test (TMT); Hopkins Verbal Learning Test (HVLT); Controlled Oral Word Association Test (COWAT) - Animals and S; Coding and Digit Span from WAIS-IV. The correlation between cognitive scores and RT dose-volume parameters to specific areas in the brain will be tested. This study will elucidate the dose-response relationship in radiation-induced damage to substructures of the brain such as hippocampus, thalamus, temporal and frontal lobes that will allow the clinician to prioritize these structures in planning of proton radiotherapy.
Investigators
Eligibility Criteria
Inclusion Criteria
- •18 years or older and Danish speaking.
- •Performance status WHO 0-2
- •Capable of cooperating on testing
- •Tumour histology (WHO 2016 classification) of the following types: anaplastic astrocytoma (IDH mutant), diffuse astrocytoma (IDH-mutant), gemistocytic astrocytoma (IDH mutant), diffuse astrocytoma (NOS), oligodendroglioma, meningioma, medulloblastoma (NOS), pituitary adenoma, other brain tumours including skull base sarcomas
Exclusion Criteria
- •Glioblastoma
- •Performance status 3-4 (Karnofsky Performances of 60 or less)
Outcomes
Primary Outcomes
Impairment of verbal learning and memory as assessed by the HVLT-r test
Time Frame: 10 Years
Examined by the Hopkins Verbal Learning Test revised. It will be correlated to the mean radiation dose to the hippocampus. Outcome is number of correct words (0-24)
Secondary Outcomes
- Processing speed I(10 years)
- Verbal fluency(10 years)
- Processing speed II(10 years)
- Attention and working memory(10 years)
- Verbal learning and memory(10 years)
- Executive function I(10 years)
- Executive function II(10 years)
- Quality of Sleep(10 years)
- Fatigue(10 years)
- Global Health - Quality of life(10 years)
- Side effects to radiation therapy(10 years)
- Depression/Anxiety(10 years)
- Patient's Assessment of Own Functioning(10 years)