Nociception Level Index (NoL) Variation After Standardized Stimulation Under General Anesthesia in Children
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Anesthesia
- Sponsor
- University Hospital, Lille
- Enrollment
- 30
- Locations
- 2
- Primary Endpoint
- NoL variation = [(Maximal NoL value in the 5 minutes following the stimulation) - (NoL before stimulation)] / [NoL before stimulation]
- Status
- Completed
- Last Updated
- 4 months ago
Overview
Brief Summary
The Nociception Level (NoL) is an index obtained via a non-invasive monitor, that is currently used to assess nociception in anesthetized adults. The NoL index varies from 0 to 100. It increases in response to nociceptive stimuli. The objective of this study was to investigate if the NoL index also indicates the level of nociception in anesthetized children. In children anesthetized according to standard practice, before surgical incision, three 5-seconds stimulations will be performed with different intensities (10, 30 and 60 milliamps). The order of the stimulations intensities will be randomized. The hypothesis of study is that the intensity of stimulation will influence the magnitude of NoL-index increase in response to the stimulation.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age 5-12 years
- •Elective surgery under general anesthesia
- •Written informed consent
Exclusion Criteria
- •Cardiac surgery
- •Opioid intake \< 24 hours before surgery
- •Cardiac arrhythmia
- •Pace maker
- •Pheochromocytoma
- •Anti-arrhythmic medication
- •Anticholinergic medication
- •Raynaud syndrome
- •Digital anomaly (malformative, traumatic)
Outcomes
Primary Outcomes
NoL variation = [(Maximal NoL value in the 5 minutes following the stimulation) - (NoL before stimulation)] / [NoL before stimulation]
Time Frame: 5 minutes after stimulation
NoL variation = \[(Maximal NoL value in the 5 minutes following the stimulation) - (NoL before stimulation)\] / \[NoL before stimulation\]
Secondary Outcomes
- Systolic Blood Pressure (SBP) variation(5 minutes after stimulation)
- Analgesia Nociception Index (ANI) variation(5 minutes after stimulation)