Usefulness of a Home-based Cognitive Monitoring in Non-demented Patients With High-risk of Dementia: a Prospective Observational Study
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- home-based cognitive monitoring score
研究概览
简要总结
This study is an observational study to confirm usefulness of a home-based cognitive monitoring in non-demented patients with high-risk of dementia
详细描述
We prospectively enroll subjects who were diagnosed as mild cognitive impairment based on neuropsychological tests battery, brain MRI, and routine blood labs including thyroid function tests, vitamine B12 & folate levels, and syphilis screening to rule out other secondary causes of dementia. We undergo peripheral blood-based amyloid beta levels and regular home-based cognitive monitoring (every 3 months) to investigate whether amyloid-positive MCIs progress rapidly using home-based cognitive monitoring during 6 months.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •persistent cognitive complaints
- •aged 50 years old or older
- •below -1.0 standard deviation in any domain of detailed neuropsychological tests battery named SNSB (Seoul neuropsychological screening battery)
- •no ADL (activities of daily living) limitation
- •subjects who agreed to participate
排除标准
- •dementia patients
- •other structural brain disorders such as hydrocephalus, hemorrhage, or tumors
- •other neurological disease such as Huntington's disease, Parkinson's disease, or epilepsy
结局指标
主要结局
home-based cognitive monitoring score
时间窗: 3 months (at baseline, 3 months from baseline, 6 months from baseline)
a 3-5 minutes brief cognitive testing (range 0\~30, higher score means better outcome) using telephone
次要结局
- Hippocampal atrophy grade(at baseline)
- Number of lacunes(at baseline)
- Number of microbleeds(at baseline)
研究者
YunJeong Hong, MD
professor
Asan Medical Center