NCT00211159已完成不适用
Omega-3 Fatty Acid Treatment of 174 Patients With Mild to Moderate Alzheimer's Disease (OmegAD): a Randomized Double-blind Trial
Karolinska University Hospital2 个研究点 分布在 1 个国家目标入组 204 人开始时间: 2000年12月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 204
- 试验地点
- 2
- 主要终点
- Cognition measured according to ADAS-cog, MMSE scales
研究概览
简要总结
Memory loss and difficulties with thinking associated with Alzheimer's disease (AD) may be due to a deficiency in the brain of a fatty acid named DHA. The aim of this trial is to see if dietary supplementation with a preparation, rich in DHA, will halt cognitive impairment in AD patients
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Alzheimer's disease with MMSE 15-30, living in own homes, treated with stable dose of acetylcholine esterase inhibitor for >3 months and remaining on that treatment for the study period
排除标准
- •Already treated with omega-3 fatty acids, NSAIDs, warfarin, being an alcohol abuser, suffering from serious concomitant disease or not having a caregiver
结局指标
主要结局
Cognition measured according to ADAS-cog, MMSE scales
次要结局
- Safety, tolerability, blood pressure
- Dose-response studies in relation to APOE4 status, to body weight and to gender(2007-2018)
- Gene expression(2007-2018)
研究者
研究点 (2)
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