Nocturnal Oxygen Treatment in Heart Failure and Cheyne-Stokes Respiration
Not Applicable
Completed
- Conditions
- Heart Failure
- Registration Number
- NCT00338078
- Lead Sponsor
- Umeå University
- Brief Summary
The purpose of this study is to determine whether oxygen therapy during sleep improves quality of life, exercise capacity and heart function among patients with chronic heart failure and central sleep apnea.
- Detailed Description
Oxygen therapy reduces the number of central apneas among patients with congestive heart failure but it is unknown whether quality of life and heart function also improve. We aim to test whether the quality of life, exercise capacity and heart function are improved with nocturnal oxygen therapy during 6 weeks with nocturnal oxygen from oxygen concentrator or nocturnal air from placebo concentrator.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 62
Inclusion Criteria
- Stable heart failure with left ventricular dysfunction
- Cheyne-Stokes respiration with central AHI>15 and obstructive AHI<5
Exclusion Criteria
- Heart infarction within 3 months.
- Dementia
- Chronic obstructive pulmonary disease and daytime hypoxemia.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Exercise capacity Quality of life (SF-36, Minnesota, Living with heart failure questionnaire) Brain natriuretic peptide (BNP)
- Secondary Outcome Measures
Name Time Method Echocardiography Radionuclide determination of ejection fraction Mortality and hospitalization for cardiovascular causes (combined and individually) Hospitality anxiety and depression scale Epworth sleepiness scale Karolinska sleepiness scale Routine lab (haemoglobins, thyroid status, creatinin) Urinary catecholamines Urinary cortisol Polysomnography Arrhythmias from 24 hour Holter-ECG registration Heart rate variability
Trial Locations
- Locations (1)
Dept of respiratory medicine
🇸🇪Umeå, Sweden