Topical Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Women Undergoing Elective Cesarean Section
Not Applicable
- Conditions
- Cesarean Section Complications
- Interventions
- Drug: Topical tranexamic acid
- Registration Number
- NCT05072860
- Lead Sponsor
- Aswan University Hospital
- Brief Summary
In hypertensive women having an elective cesarean section, the effectiveness and safety of temporary uterine packing coupled with topical tranexamic acid as an adjuvant for decreasing blood loss during delivery were compared to placebo.
- Detailed Description
patients were allocated to one of two groups after induction of anesthesia. they received temporary uterine packing with gauze of the dimensions soaked with 2 gm tranexamic diluted in 60ml saline acid or placebo
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 150
Inclusion Criteria
- hypertensive women undergoing elective cesarean section
Exclusion Criteria
- Patients with cardiac, hepatic, renal, or thromboembolic disease. ,
- patients with the high possibility of the morbid adherent placenta,
- known coagulopathy and
- those presented with severe antepartum hemorrhage
- refuse to participate
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Topical tranexamic acid Topical tranexamic acid temporary uterine packing with gauze of the dimensions soaked with 2 gm tranexamic diluted in 60ml saline acid or placebo
- Primary Outcome Measures
Name Time Method intraoperative blood loss 30 minutes measures the intraoperative blood loss by direct and gravimetric methods
- Secondary Outcome Measures
Name Time Method need of uterotonic 24 hours misoprostol, oxytocin etc
change in hemoglobin 24 hours change in hemoglobin
need of blood transfusion 12 hours number of unites of blood transfusion