Investigating the Effect of Oxytocin and the Neurochemistry of Antisocial Personality Disorder and Psychopathy Using Neuroimaging
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- Within-group effect of oxytocin on nerual modulation of fear
研究概览
简要总结
A pharmacoimaging study of oxytcoin in antisocial personality disorder and psychopathy
详细描述
Using a double-blinded, placebo controlled design, we explored similarities and differences in i) an important component of empathic processing (neural response to facial emotional expressions) and ii) decision-making in violent men with ASPD+/-Psychopathy, compared to healthy non-offenders (NO; n= 21 across studies), with placebo and after acute application of intranasal oxytocin, using functional Magnetic Resonance Imaging (fMRI).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Triple (Participant, Care Provider, Investigator)
盲法说明
Double-blinded- participant and investigator.
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Aged 18-60
- •IQ greater than 70 as defined by the Wechsler Abbreviated Scale of Intelligence (WASI-II).
- •Violent offenders:
- •Offenders with convictions for violent crimes (murder, rape, attempted murder, grievous and actual bodily harm) who met DSM-5 criteria for antisocial personality disorder (Structured Clinical Interview for DSM-5 Personality Disorders (SCID-5 PD) Psychopathy or non-psychopathy subgroup based on Psychopathy Checklist- Revised (PCL-R; (Hare, 2003))- score of 25 as the threshold for psychopathy in this English population.
- •Healthy non-offenders:
- •Non-offenders with no personality disorder
- •Exclusion criteria:
- •history of major mental disorders (bipolar 1, bipolar 2, major depression or psychotic disorders)
- •self-reported neurological disorders
- •head injury resulting in loss of consciousness for 1 hour or longer
- •severe visual or hearing impairments
- •contraindications to MRI
排除标准
- 未提供
研究组 & 干预措施
Violent offenders with psychopathy
Violent offenders with psychopathy
干预措施: Oxytocin nasal spray (Drug)
Violent offenders with psychopathy
Violent offenders with psychopathy
干预措施: Placebo spray (Other)
Violent offenders without psychopathy
Violent offenders without psychopathy
干预措施: Oxytocin nasal spray (Drug)
Violent offenders without psychopathy
Violent offenders without psychopathy
干预措施: Placebo spray (Other)
Healthy non-offenders
Healthy non-offenders
干预措施: Oxytocin nasal spray (Drug)
Healthy non-offenders
Healthy non-offenders
干预措施: Placebo spray (Other)
结局指标
主要结局
Within-group effect of oxytocin on nerual modulation of fear
时间窗: 10 minutes
Differences in responsivity to morphed faces on FMRI in oxytocin vs fear condition- clusterwise analysis using AFNI (effect size is beta values)
次要结局
- Baseline neural modulation of morphed fearful faces(10 minutes)