Photodynamic therapy with toluidine blue (t-bu) in the treatment of periodontitis in type 2 diabetic patients

Not Applicable

Recruiting

• Conditions: Diabetes Mellitus Type 2; Periodontitis; C18.452.394.750

• Registration Number: RBR-4yhwvvc
• Lead Sponsor: niversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatuba

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-12-06
• Last Update Posted: 19 December 2023
• Study Completion: 2024-12-01

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Patients aged = 30 and = 70 years; diagnosis of periodontitis according to the new classification with interproximal clinical attachment level (CAL) = 2 or CIN = 3 mm in more than 2 non-adjacent teeth (excluding the CAL limits cited in cases related to periodontitis: gingival recession of traumatic origin; caries; teeth extending into the cervical area of ??the teeth; presence of CAL distally to the second molar and associated with poor dental position or extraction of the third molar; endodontic lesion reaching the gingival margin and occurrence of vertical root fracture); who have undergone periodontal treatment within a maximum period of 3 months with at least 4 sites with PD =4mm with BOP; patients diagnosed with type 2 diabetes mellitus (HbA1c = 7.0%); have at least 15 teeth, excluding third molars

Exclusion Criteria

Smokers or ex-smokers for more than 5 years; patients with anemia; patient with active cancer and history of chemotherapy; antibiotic therapy within the previous 6 months; hx of anti-inflammatory therapy in the past 6 months; patient with blood disorders; pregnancy; patient undergoing orthodontic treatment, patients requiring prophylactic antibiotic therapy

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical attachment gain 6 months after treatment, verified by periodontal probing, to verify a variation of 1mm of clinical periodontal attachment before and after the intervention

Secondary Outcome Measures

Name	Time	Method
Variation in the values ??of the laboratory test for glycated hemoglobin at 180 days after treatment, verified through laboratory analysis with the percentage rate, to verify the percentage variation in the levels of circulating glycated hemoglobin in the blood before and after the intervention<br>