ong-term safety of preimplantation genetic diagnosis Follow-up of 5 and 8-year old children born after PGD
Recruiting
- Conditions
- Children born after PGD10083624
- Registration Number
- NL-OMON47126
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 300
Inclusion Criteria
5-year old children, singleton or part of twins or triplets, born after either PGD, spontaneous conception after their parents have considered PGD or have undergone prenatal diagnosis (chorionic villus biopsy or amniocentesis) or after IVF/ICSI. At least one of the parents of the children must be willing to participate.
Enough competence of the the Dutch language ;8-year old children who have participated in het follow up study at the age of 5
Exclusion Criteria
Children with known chromosomal abnormalities or gene disorders
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Major malformation rate, general health, cognitive and socioemotional<br /><br>development, parent-child interaction and parental stress. </p><br>
- Secondary Outcome Measures
Name Time Method <p>-most important factors in the decision making process of whether to opt for<br /><br>PGD treatment (for parents of 5 year old children)<br /><br>-the presence of clinically relevant imprinting defects (future study for 5 and<br /><br>8 year old children)<br /><br>- cardiovascular evaluation (8 year old children)</p><br>