Mechanisms of Myocardial Infarction in Women With Non Obstructive Coronary Artery Disease

• Conditions: Myocardial Infarction
• Interventions: Procedure: cardiac imajing

• Registration Number: NCT01953029
• Lead Sponsor: Rambam Health Care Campus

Brief Summary

The objective of our work to determine the mechanisms of myocardial infarction in women without obstructive coronary artery disease.

Detailed Description

Cardiovascular disease is the leading cause of death for women. Acute coronary syndrome (ACS) is usually characterized by a sudden erosion of the endothelial wall or rupture of a plaque.However, women with ACS are less likely than men to have either classic symptoms or obstructive coronary artery disease but paradoxically have a worse prognosis. Different data from the literature indicate that there may be different pathophysiological mechanisms, afflicting men and women somewhat differently.Between 5% and 30% of patients with ACS undergoing coronary angiography are found to have non visible or non obstructive coronary disease (NOCD). This is 2-3 times more common in women than in men. Several pathogenetic mechanism of myocardial infarction (MI) in the absence of obstructive coronary artery disease (OCD) have been postulated, including among others atherosclerosis with plaque disruption that does not lead to luminal occlusion ,endothelial dysfunction, vasospasm , distal microembolization and microvascular dysfunction. However the data are extremely limited.

Study Timeline

• Status Verified: 2013-09
• Study First Submitted: 2013-09-23
• Study First Submitted QC: 2013-09-25
• Last Update Submitted: 2013-09-25
• Study First Posted: 2013-09-30
• Last Update Posted: 2013-09-30
• Study Start: 2013-12
• Primary Completion: 2016-10
• Study Completion: 2018-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

• Women ≥ 18 years old, not pregnant
• with acute non ST elevation myocardial infarction (admitted within 12 hours from beginning of symptoms)
• who are candidates for coronary arteriography during the hospitalization. -

Exclusion Criteria

*Women with troponin elevation caused by other causes -

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
non obstructive coronary disease	cardiac imajing	non obstructive coronary disease

Primary Outcome Measures

Name	Time	Method
MORTALITY	1 YEAR

Trial Locations

Locations (1)

Rambam Heath Care Campus; 🇮🇱 Haifa, Israel