NCT01818453已完成不适用
Genetic Predictors of Response to a Computerized Self-help Program for Depression
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 500
- 试验地点
- 2
- 主要终点
- Quick Inventory of Depressive Symptomatology (Self-Report) (QIDS-SR-16)
研究概览
简要总结
The goal of this project is to determine whether genetic information can be used to predict response to an internet-based treatment of depression. Several studies now indicate that completing an internet-based treatment for depression, called Deprexis, can significantly improve symptoms of depression. However, not everyone improves. The purpose of this study is to determine whether genetic profile can predict who is likely to improve.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •English-speaking
- •Have reliable access to the internet (i.e., dialup or broadband access)
- •Be willing to donate saliva for DNA research
- •Have a current symptoms of depression
- •Be stable on medication and/or therapy (i.e. no changes within 2 weeks of study entry)
排除标准
- •Any diagnosis of a psychotic or bipolar disorder
- •Meeting for alcohol/drug dependence in the past year
- •Having current suicidal risk warranting crisis intervention
结局指标
主要结局
Quick Inventory of Depressive Symptomatology (Self-Report) (QIDS-SR-16)
时间窗: Administred every 2 weeks while the participant is engaged in the online deprexis treatment program to measure depression symptom severity.
次要结局
- Inventory of Depression and Anxiety Symptoms (IDAS)(The IDAS will be completed as part of the pre- and post-treatment questionnaires to assess for symptoms of depression and anxiety.)
- Massachusetts General Hospital Antidepressant Treatment History Questionnaire (ATRQ)(The ATRQ will be administered as part of the pre-treatment questionnaires to evaluate psychotropic efficacy.)
- Hamilton Depression Rating Scale (HAM-D)(The HAM-D will be completed during the pre- and post-treatment phone interviews to assess depression symptom severity.)
- Psychiatric Diagnostic Screening Questionnaire (PDSQ)(The PDSQ will be completed as part of the pre- and post-treatment questionnaires to screen for the most common DSM-IV Axis I disorders..)
- Risky Families Questionnaire (RFQ)(The RFQ will be completed as part of the pre-treatment questionnaires to assess early familial experiences and the harshness of family climate.)
- Sheehan Disability Scale (SDS)(The SDS will be completed as part of the pre- and post-treatment questionnaires to evaluate symptom-related disability.)
研究者
Christopher G. Beevers
Professor
University of Texas at Austin
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Design of a Genetic Score to Predict the Response to a Dietary Intervention in Adults With Metabolic SyndromeMetabolic SyndromeNCT05495074Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran115
终止
不适用
Genetic Basis for Prediction of Non-responders to Dietary Plant Sterol InterventionCardiovascular DiseaseHypercholesterolemiaNCT02765516University of Manitoba43
招募中
不适用
Toxicity Genetic Determinants and Response to Azacitidine and Venetoclax in AMLLeukemia, Myeloid, AcuteNCT06580106Wake Forest University Health Sciences50
进行中（未招募）
不适用
Investigation of genetic predictors of the response to SSRI treatment in patients with panic disorderpanic disorderEUCTR2007-002649-19-EETartu University Hospital Psychiatry Clinic500
已完成
不适用
Fenofibrate and Pharmacogenetic Impact in DyslipidemiaDyslipidemiaNCT00613613University of Minnesota56