IRCT20181224042104N1
Recruiting
Phase 2
Determination of efficacy and safety of adding Oxaliplatin to neoadjuvant chemotherapy in locally advanced breast cancer patients
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Shiraz University of Medical Sciences
- Enrollment
- 30
- Status
- Recruiting
- Last Updated
- 7 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Histologically confirmed locally advanced breast cancer
- •Clinical stage T3, T4, and/or N2, N3
- •Patients with Eastern Cooperative Oncology Group performance status of 0 or 1
- •Absolute neutrophil count \> 1500/ mm3
- •Hemoglobin \> 8\.0 g/dL
- •Platelet count \> 100,000/mm3
- •Creatinine \< 2\.5 times the upper limit of normal (ULN)
- •Serum transaminases \< 2\.5 times ULN
- •Serum alkaline phosphatase \< 4 times ULN
- •Total bilirubin \< 2\.5 times
Exclusion Criteria
- •Active infection
- •Other primary malignancy
- •Any documented distant metastasis
- •Uncontrolled systemic diseases (including severe cardiovascular, kidney and liver disease)
- •Patients refusal to participate in the trial
Outcomes
Primary Outcomes
Not specified
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