Stress, habits and attachment in obsessive-compulsive disorder (SHA-OCD)

Not Applicable

Completed

• Conditions: Obsessive-compulsive disorder; Mental and Behavioural Disorders

• Registration Number: ISRCTN47698087
• Lead Sponsor: Zon MW

Brief Summary

2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32094333/ (added 27/03/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2018-10-11
• Study Start: 2019-02-21
• Last Update Posted: 10 April 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

Patients:
1. Diagnosis of OCD with obsessions and compulsions assessed with the MINI Neuropsychiatric Interview (MINI)
2. Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score cut-off of 12
3. 18-65 years of age
4. Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements

Controls:
1. 18-65 years of age
2. Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements

Exclusion Criteria

Patients:
1. Current major depressive disorder, bipolar disorder, psychotic disorder, alcohol or substance dependence, or any cognitive disorder as assessed with the MINI
2. Major head trauma or neurological disease, current or in history
3. MRI contraindications such as metal implants, claustrophobia, left-handedness, pregnancy
4. Self-reported inability or unease to cease smoking for 3 hours prior to testing
5. Endocrinological disorders or regular use of corticosteroids
6. Current treatment with antipsychotic medication
7. Use of other psychotropic medication (apart from SSRI's or tricyclic antidepressant), or of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before each measurement
8. Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel).

Controls:
1. Current or past psychiatric diagnosis as assessed with the MINI
2. Major head trauma or neurological disease, current or in history
3. MRI contraindications such as metal implants, claustrophobia, pregnancy
4. Self-reported inability or unease to cease smoking for 24 hours prior to testing
5. Endocrinological disorders or regular use of corticosteroids
6. Use of psychotropic medication, or of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before each measurement
7. Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel).

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. Whether stress facilitates a shift from goal-directed to habitual behaviour measured using behavioral data from a two-step sequential choice task that differentiates between model-free (habitual) and model-based (goal-directed) behavioral strategies.<br> 2. Subjective anxiety ratings on a self-rating scale in response to visual OCD-related, general fearful and neutral stimuli.<br> 3. Brain activity during at rest and during tasks measured using fMRI voxel-based signal covariation with task parameters.<br>

Secondary Outcome Measures

Name	Time	Method
<br> 1. Whether stress results in heightened amygdala response to biologically salient stimuli fMRI voxel-based signal covariation with task parameters.<br> 2. How stress affects the functional integrity of the goal-directed and habit networks measured using a seed-to-voxel analysis.<br> 3. Structural integrity of the implicated neural networks as measured with DTI tractography<br> 4. Individual attachment style measured with the Adult Attachment Interview (semi-structured interview) and Experiences in Close Relationships scale (self-report scale)<br>