Efficacy of Preemptive Volume Loading to Prevent Arterial Hypotension During Induction of General Anesthesia
Overview
- Phase
- Phase 4
- Intervention
- Gelatin 500 mL
- Conditions
- Anesthesia
- Sponsor
- Hopital Foch
- Enrollment
- 17
- Locations
- 1
- Primary Endpoint
- Hypotension
- Status
- Terminated
- Last Updated
- 9 years ago
Overview
Brief Summary
Induction of general anesthesia induces frequently arterial hypotension. The short term goal of this study is to evaluate if preemptive volume loading prevents such complication.
Detailed Description
This is a randomized, prospective study which will include a total of 200 patients who are scheduled to undergo elective surgery. The research participants will be randomly assigned to * a control group that will receive a low preemptive volume loading (50 mL of gelatin), * a protocol group that will receive a high preemptive volume loading (500 mL of gelatin). Volume loading is preceded by the measurement of stroke volume and cardiac output before and after a passive leg elevation test and followed by a standardized anesthetic protocol.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adult patients undergoing elective surgery.
Exclusion Criteria
- •Difficult peripheral venous access
- •Allergy to gelatin
- •Symptomatic cardiac disease, rhythm trouble, pace-maker, aortic valvular disease, aortic disease
- •Morbid obesity, low BMI,
- •hypovolemia,
- •Raynaud syndrome or scleroderma,
- •Contra-indication to propofol, remifentanil or to the use of Bispectral Index,
- •Hematocrit \< 20%.
Arms & Interventions
High pre-emptive volume loading
Intervention: Gelatin 500 mL
Low pre-emptive volume loading
Intervention: Gelatin 50 mL
Outcomes
Primary Outcomes
Hypotension
Time Frame: 30 minutes
mean arterial pressure less than 70% of the baseline measurement
Secondary Outcomes
- hemodynamic effect of leg passive elevation test(30 minutes)
- hemodynamic effect of volume loading(30 minutes)
- heart rate monitoring(30 minutes)
- propofol dose when bispectral index is 50(30 minutes)
- propofol site effect concentration when bispectral index is 50(30 minutes)
- arterial pressure monitoring(30 minutes)