NCT03610906Enrolling By Invitation不适用
Advancing Treatment for Pediatric Craniopharyngioma: Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical Therapy
适应症
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- Identification of Potential Therapeutic Targets
研究概览
简要总结
New data suggests that the current treatment for pediatric adamantinomatous craniopharyngioma (CPA) may not be as effective as it could be.
详细描述
Current treatment regimens for pediatric CPA are limited to surgery and radiation therapy. This pilot study seeks to identify biologically rational therapeutics for the medical treatment of adamantinomatous CPA by confirming the overexpression of specific molecules.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Days 至 21 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients between 0-21 years of age.
- •Patients with the diagnosis or clinical suspicion of craniopharyngioma in whom planned clinical management will include tissue sampling.
排除标准
- •Patients in whom final pathology does not demonstrate adamantinomatous craniopharyngioma
- •Patients in whom tissue specimen is not obtained/available
- •Patients over 21 years of age.
- •Patients who choose not to participate
结局指标
主要结局
Identification of Potential Therapeutic Targets
时间窗: Beginning of study to end of study, up to 1 year.
Investigators will identify potential therapeutic targets through mRNA expression.
次要结局
- Progression Free Survival (PFS)(Beginning of study up to age 21 or death, whichever comes first.)
- Visual Deficit Assessment(At 6 and 12 months after the specimen sample was taken.)
- Pituitary Function Assessment(At 6 and 12 months after the specimen sample was taken.)
- Survival(Beginning of study up to age 21 or death, whichever comes first.)
研究者
研究点 (1)
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