The Role of Conditioning for Pharmacotherapeutic Treatments in Rheumatoid Arthritis. - Conditioning in Rheumatoid Arthritis.

niversiteit Leiden0 个研究点目标入组 94 人开始时间: 待定最近更新: 2024年6月11日

适应症

试验速览

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•Adult (minimum age of 18 years), recent-onset RA, fluent in Dutch, able to give informed consent, in clinical remission at month 5 after completing the protocolized pharmacological treatment.

•- Pregnancy or wish to become pregnant during the study, or childbearing potential without adequate contraception.
•- Concomitant treatment with another experimental drug.
•- History or presence of malignancy within the last five years.
•- Bone marrow hypoplasia.
•- Elevated hepatic enzyme levels (ASAT, ALAT > 3 times normal value).
•- Serum creatinine levels > 150 umol/l or estimated creatinine clearance of < 75%.
•- Uncontrolled diabetes mellitus (according to the rheumatologist).
•- Uncontrolled hypertension or moderate to severe heart failure (NYHA class III/IV).
•- Alcohol or drug abuse.
•- History of infected joint prosthesis within the previous 3 months.
•- Serious infections, such as hepatitis, pneumonia, pyelonephrititis in the previous 3 months.
•- Chronic infectious disease such as chronic renal infection, chronic chest infection with bronchiectasis or sinusitis.
•- History of opportunistic infections such as herpes zoster within previous 2 months.

发起方

niversiteit Leiden