The Fasting and Shifted Timing (FAST) of Eating Study

Not Applicable

Completed

• Conditions: Overweight and Obesity
• Interventions: Behavioral: Online handouts describing how to follow each diet for 1 week each

• Registration Number: NCT04527952
• Lead Sponsor: University of South Carolina

Brief Summary

The aim of this study is to assess peoples' satisfaction with their diet based on adhering to three different meal-timing protocols for one week each: (1) Time-restricted feeding (TRF); (2) Intermittent fasting (IF); and (3) Alternate day fasting (ADF). The overall goal of this study is to determine if people would find it easy or difficult to follow these diet protocols for the purpose of weight management.

Detailed Description

Fasting and time-restricted feeding (TRF) have become increasingly popular in nutrition research due to the potential health benefits they may provide. Several animal studies, and more recently some human studies, have indicated regular meal-timing (i.e. eating mostly in the day) or fasting have been beneficial for controlling weight, blood pressure, cholesterol, glucose, and insulin sensitivity.

These types of eating patterns may offer the same "anti-aging" health benefits as traditional caloric restriction (i.e. consistent and routine adherence to a very low-calorie diet).While caloric restriction is considered the gold standard for weight management, weight regain often limits the long-term effectiveness of this approach. People often experience increases in hunger, which make it difficult to sustain this type of behavior.Therefore, researchers are turning to these dietary approaches as alternatives to low-calorie diets in an effort to obtain the same benefits, but with less burden on participants.

However, it is not clear if the adherence to these types of diet protocols are any better than a low-calorie diet. Would people be more satisfied with meal-timing or fasting over a traditional very low-calorie diet? That is the main research question of this study.

Study Timeline

• Study Start: 2019-06-19
• Primary Completion: 2020-07-31
• Study Completion: 2020-08-01
• Study First Submitted: 2020-08-19
• Study First Submitted QC: 2020-08-21
• Study First Posted: 2020-08-27
• Status Verified: 2021-04
• Last Update Submitted: 2021-04-26
• Last Update Posted: 2021-04-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• Be 18 years or older.
• Have a BMI between 25 - 49.9 kg/m2.
• Have a scale at home, or some way of weighing yourself regularly, so that you can report your body weight to the research staff.
• Be able to check emails regularly, because all of the surveys need to be completed online.

Exclusion Criteria

• NOT be already practicing any of these fasting approaches.
• NOT currently diagnosed with diabetes.
• NOT taking any appetite suppressants or prescription weight loss medications.
• NOT planning on getting pregnant within the next 6 weeks.
• Do NOT currently have any eating disorders.
• Have NOT lost or gained a significant amount of weight (i.e. 10 pounds or more) within the last 6 months.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Alternate day fasting (ADF)	Online handouts describing how to follow each diet for 1 week each	This involves complete fasting (i.e. no food or caloric containing beverages, only water consumption) for roughly an entire 36-hour period, followed by an ad libitum feeding day.
Time-restricted feeding (TRF)	Online handouts describing how to follow each diet for 1 week each	Participants will eat the majority of their calories in the day. More specifically participants will consume 70% of their total calories before 5 pm and the remaining 30% after 5 pm.
Intermittent fasting (IF)	Online handouts describing how to follow each diet for 1 week each	This involves eating all of one's meals within a specific time (e.g. 8 hours) frame and fasting for the remaining hours (16 hours) in a day.

Primary Outcome Measures

Name	Time	Method
Weight loss- week 3	1 week	We will assess weight loss via self-report after 1 week on diet #3
Weight loss- week 2	1 week	We will assess weight loss via self-report after 1 week on diet #2
Weight loss-week 1	1 week	We will assess weight loss via self-report after 1 week on diet #1

Secondary Outcome Measures

Name	Time	Method
Energy intake- week 2	6 weeks	Energy (kcal) intake will be assessed after 1 week on diet #2
Energy intake-week 1	6 weeks	Energy (kcal) intake will be assessed after 1 week on diet #1
Energy intake- week 3	6 weeks	Energy (kcal) intake will be assessed after 1 week on diet #3

Trial Locations

Locations (1)

University of South Carolina; 🇺🇸 Columbia, South Carolina, United States