The Effect of Inhaled Salmeterol on Inflammation after Bronchial Instillation of Allergen or Allergen/Lipopolysaccharide in Asthma. - Effect of Salmeterol on Allergic Inflammation

Academisch Medisch Centrum0 个研究点目标入组 32 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•* Intermittent to mild asthmatics between 18 and 45 years of age
•* Allergy for house dust mite documented by a positive RAST
•* No clinically significant findings during physical examination and hematological and biochemical screening
•* At spirometry FEV1 more than 70% of predicted value
•* Stable asthma while treated with fluticasone propionate 100*g bid during 2 weeks before the study.

•* Comorbidity
•* A history of smoking within the last 12 months, or regular consumption of greater than three units of alcohol per day
•* Exacerbation and/or the use of oral steroids within the 4 weeks before start of run in.
•* Administration of any investigational drug within 30 days of study initiation
•* Donation of blood within 60 days, or loss of greater than 400 ml of blood within 12 weeks of study initiation
•* History of enhanced bleeding tendency
•* History of serious drug-related reactions, including hypersensitivity
•* Inability to use only the run-in medication plus salbutamol rescue medication supplied for this study. If subjects use other pulmonary medications these will be replaced by the run-in medication.

发起方