Right Ventricular Pulmonary Vascular Interaction in Pulmonary Hypertension
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 主要终点
- The primary outcome is to comprehensively quantify right ventricular and pulmonary vascular function at rest and with exercise using magnetic resonance imaging.
研究概览
简要总结
The goals of this study were two-fold. First, the attempt to quantify the relationships between pulmonary arterial stiffness, right ventricular function and the efficiency of ventricular-vascular interactions in patients with pulmonary arterial hypertension (PAH). Second, the attempt to quantify the effects of exercise on pulmonary arterial stiffness, pulmonary vascular resistance, right ventricular function and the efficiency of ventricular-vascular interactions in patients with PAH.
详细描述
The goals of this study are to quantify right ventricular-pulmonary vascular interactions in different types of PAH, to determine the temporal changes in these interactions with PAH progression and to quantify the effects of exercise on right ventricular function. The inclusion of the subpopulation of PAH patients with systemic sclerosis (SSc) was a result of the anticipation that this group has worse arterial stiffening than other groups, and consequently more inefficient right ventricular-pulmonary vascular interactions, which account for their worse prognosis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of pulmonary arterial hypertension or a subtype
- •Referred for right heart catheterization
- •Age between 18 and 80 years
- •New York Heart Association (NYHA) functional class I, II, or III
排除标准
- •Recent syncope (within 1 year)
- •Severe skeletal or muscle abnormalities prohibiting exercise
- •Mixed etiology pulmonary arterial hypertension
- •Severe lung disease
- •Test results indicating severe obstruction
- •Total lung capacity < 60%
- •Pregnancy or breastfeeding
- •NYHA class IV patient
- •Contraindications to magnetic resonance imaging
- •Kidney dysfunction as determined by an estimated glomerular filtration rate (eGFR) of < 30 mL/min/1.73m2
- •Contraindication to gadolinium
研究组 & 干预措施
Patient
A research MRI scan with exercise will be obtained in conjunction with standard of care cardiopulmonary testing.
干预措施: Magnetic Resonance Imaging (MRI) with exercise (Device)
结局指标
主要结局
The primary outcome is to comprehensively quantify right ventricular and pulmonary vascular function at rest and with exercise using magnetic resonance imaging.
时间窗: Up to 24 months
The hypotheses will be tested by comprehensively quantifying ventricular and vascular function in subjects with idiopathic pulmonary arterial hypertension, systemic sclerosis pulmonary arterial hypertension, and chronic thromboembolic pulmonary hypertension, using investigational magnetic resonance angiography techniques.
次要结局
未报告次要终点