CRP-guided antibiotic treatment in patients hospitalized with acute exacerbation of COPD patients. The CATCH (CRP guided Antibiotic Treatment in COPD exacerbations admitted at the Hospital) study. - CRP-guided therapy in AECOPD (Acute Exacerbation of COPD)

Medisch Centrum Alkmaar0 个研究点目标入组 220 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•Age 40 or over. No upper age limit will be employed.
•Written informed consent obtained.
•Change in the patient*s baseline dyspnoea, cough, and/or sputum that is beyond normal day-to-day variations, is acute in onset, and may warrant a change in regular medication in a patient with underlying COPD.
•Patients have to be capable of ingesting oral medication.
•Patients have to mentally capable of participating in the study (able to complete questionnaires and perform lung function tests).
•Life expectancy >= 30 days.
•Smoking history > 10 packyears

•Exclusion criteria
•Pregnant or lactating women
•Pretreatment with corticosteroids (cumulative dosis >210 mg) for the present exacerbation.
•Progression or new radiographic abnormalities on the chest X-ray.
•Bronchiectasis (HRCT confirmed).
•Cystic fibrosis
•Tuberculosis
•Immunodeficiency disorders such as AIDS, humoral immune deficiency, ciliary dysfunction etc., and the use of immunosuppressive drugs (>30 mg prednisolone maintenance dose or equivalent for more than 4 weeks).
•Recent or unresolved lung malignancy.
•Other disease likely to require antibiotic therapy, such as recurrent sinusitis or urinary tract infection.
•Significant gastrointestinal or other conditions that may affect study drug absorption.
•Class III or IV congestive heart failure or stroke.
•Newly diagnosed pulmonary embolism
•Chonic incresead CRP of any cause (history, lab exam)

发起方

Medisch Centrum Alkmaar