Facing multidrug-resistant pathogens in periprosthetic joint infections with self-administered outpatient parenteral antimicrobial therapy (S-OPAT) — A prospective cohort study

Recruiting

Conditions: T84.5
Infection and inflammatory reaction due to internal joint prosthesis

Registration Number: DRKS00021135

Lead Sponsor: BG University Hospital Bergmannsheil

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 45

Inclusion Criteria

The inclusion criterion was the detection of a pathogen that could not be optimally treated with oral antibiotics according to the PRO-IMPLANT Foundation based on the management concept of Zimmerli et al. and adapted by Trampuz et al.

Exclusion Criteria

Patients with a mental disability or paraplegic symptoms are excluded.

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome is the successful infection eradication of multidrug-resistant (MDR) pathogens in periprosthetic joint infections with self-administered outpatient parenteral antimicrobial therapy (S-OPAT) in multi-stage revision arthroplasty. It is characterized by reimplantation of a prosthesis and completion of the antimicrobial therapy with an average duration time of 12 weeks.<br><br>Patients are included in an ongoing follow-up to obtain data from long-term results, following the international consensus of successful PJI treatment by Diaz-Ledezma et al.

Secondary Outcome Measures

Name	Time	Method
I) Evaluation of long-term outcome (10 years after the end of treatment)<br><br>II) Assessment of complications related to APAT:<br>1) Adverse drug reactions (ADRs)<br>2) Catheter-related complications (CRC)<br><br>Patients visited the hospital or their general practitioners at least once a week for follow-up clinical examination.