A Novel Neuromonitoring Guided Cognitive Intervention for Targeted Enhancement of Working Memory
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 65
- 试验地点
- 2
- 主要终点
- Change in Working Memory Performance
研究概览
简要总结
The proposed study is to test and validate a novel intervention that integrates computerized cognitive training with real-time neuromonitoring and neurofeedback to enhance working memory by probing the individualized neural systems underlying working memory. We will test the proposed intervention on children with ADHD with working memory deficits. The R61 proof-of-concept phase will assess the target engagement, effective dose and feasibility.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 7 Years 至 11 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Change in Working Memory Performance
时间窗: baseline and 6 weeks
Accuracy in an N-back working memory task was calculated as the percentage of correct responses to target stimuli.
Change in Target Frontal-parietal Activity
时间窗: baseline and 6 weeks
Change in activity in the target frontal-parietal network measured by functional near infrared spectroscopy (fNIRS) during an N-back working memory task. A general linear model is applied to recorded signal and the beta coefficients from the model are extracted as a proxy for brain activity in fronto-pariteal network which subserves working memory function. There is no established population mean for beta coefficient of brain activity. Higher (lower) beta coefficients reflect higher (lower) activation in the target brain network. A positive change indicates increased brain activity. Increased frontal-parietal activity reflects better engagement of this brain network during working memory performance.
次要结局
- Change in Conners 3rd Edition Inattention T-score(baseline and 6 weeks)
- Change in Conners 3rd Edition ADHD Index Score(baseline and 6 weeks)
- Change in Wide Range Assessment of Memory and Learning 2 (WRAML-2), General Memory Index Score(baseline and 6 weeks)
- Change in Behavior Rating Inventory of Executive Function (BRIEF), Working Memory T-score(baseline and 6 weeks)
- Change in Developmental NEuroPSYchological Assessment II (NEPSY-II) Composite Score(baseline and 6 weeks)
研究者
Hadi Hosseini
Assistant Professor
Stanford University