Study of the Colonic Carriage of Staphylococcus Aureus in a Prospective Cohort of Patients Undergoing Endoscopic Screening for Digestive Cancer in the University Hospital of Saint-Etienne

Not Applicable

Completed

• Conditions: STAPHYLOCOCCAL INFECTIONS
• Interventions: Other: Staphylococcus aureus carriage

• Registration Number: NCT02502474
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

Epidemiological study aiming to describe the carriage (nasal, throat, groin, rectal and colonic) of S. aureus in patients without chronic digestive disease who are going to have a colonoscopy for cancer screening. The carriage will be analyzed globally and the similarity of strains isolated from each site will be analyzed using molecular tools. The aim of this study is to better estimate the digestive reservoir of S. aureus to better prevent endogenous infections due to this bacterium.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-02-02
• Study First Submitted: 2015-07-15
• Study First Submitted QC: 2015-07-16
• Study First Posted: 2015-07-20
• Primary Completion: 2017-10-20
• Study Completion: 2017-10-20
• Status Verified: 2018-09
• Last Update Submitted: 2018-09-27
• Last Update Posted: 2018-09-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 112

Inclusion Criteria

• Patient affiliated to French social security
• Written consent of the patient
• Patient needing a colonoscopy in the University Hospital of Saint-Etienne, France

Exclusion Criteria

• Patient who decline to participate to the study
• Patient in the incapacity to give consent
• Patient receiving treatment with anticoagulant or antiaggregant platelets
• Patients with a known haemostatic disorder
• Pregnant woman
• Patients with a chronic disease of the gastrointestinal tract
• Patients receiving long-term corticosteroid
• Patient receiving anti staphylococcal antibiotics

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Patients undergoing a colonoscopy	Staphylococcus aureus carriage	Staphylococcus aureus carriage is measured in nose, throat, colon, rectum and groin

Primary Outcome Measures

Name	Time	Method
Number of patient with Staphylococcus aureus colonic carriage	Day 1	Staphylococcus aureus carriage in the colon is measured by biopsy

Secondary Outcome Measures

Name	Time	Method
Number of patient with Staphylococcus aureus carriage in the nose	Day 1	Staphylococcus aureus carriage in the nose is measured by swab culture.
Number of patient with similar Staphylococcus aureus strains in the nose and in the rectum	Day 1	Staphylococcus aureus carriage in the rectum and in the nose is measured by swab culture
Number of patient with Staphylococcus aureus carriage in the throat	Day 1	Staphylococcus aureus carriage in the throat is measured by swab culture.
Number of patient with Staphylococcus aureus carriage in the groin	Day 1	Staphylococcus aureus carriage in the groin is measured by swab culture.

Trial Locations

Locations (1)

CHU Saint-Etienne; 🇫🇷 Saint-Etienne, France