Neurobehavioral Mechanisms of Cocaine Choice
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative
研究概览
简要总结
The objective of this protocol is to use a drug-vs-money choice task, reinforcement learning modeling and fMRI to determine the neurobehavioral and neurobiological decision-making "profile" associated with the decision to take cocaine and the reduced cocaine choice that occurs during a behavioral intervention (alternative money reinforcer) that models contingency management.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
Cocaine dose is administered under double-blind conditions. Available money value is not masked.
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Recent cocaine use, otherwise healthy
排除标准
- •Laboratory results outside of clinically acceptable ranges, history of or current serious physical or psychiatric disease
研究组 & 干预措施
$0.25 alternative reinforcer value
Subjects complete 200 trials on a probabilistic concurrent choice procedure in which 3 mg/70 kg intravenous cocaine and an alternative monetary reinforcer are available during each trial. Each money value is tested in a separate session.
干预措施: Money (Behavioral)
$0.25 alternative reinforcer value
Subjects complete 200 trials on a probabilistic concurrent choice procedure in which 3 mg/70 kg intravenous cocaine and an alternative monetary reinforcer are available during each trial. Each money value is tested in a separate session.
干预措施: Cocaine HCl (Drug)
$1.00 alternative reinforcer value
Subjects complete 200 trials on a probabilistic concurrent choice procedure in which 3 mg/70 kg intravenous cocaine and an alternative monetary reinforcer are available during each trial. Each money value is tested in a separate session.
干预措施: Money (Behavioral)
$1.00 alternative reinforcer value
Subjects complete 200 trials on a probabilistic concurrent choice procedure in which 3 mg/70 kg intravenous cocaine and an alternative monetary reinforcer are available during each trial. Each money value is tested in a separate session.
干预措施: Cocaine HCl (Drug)
$4.00 alternative reinforcer value
Subjects complete 200 trials on a probabilistic concurrent choice procedure in which 3 mg/70 kg intravenous cocaine and an alternative monetary reinforcer are available during each trial. Each money value is tested in a separate session.
干预措施: Money (Behavioral)
$4.00 alternative reinforcer value
Subjects complete 200 trials on a probabilistic concurrent choice procedure in which 3 mg/70 kg intravenous cocaine and an alternative monetary reinforcer are available during each trial. Each money value is tested in a separate session.
干预措施: Cocaine HCl (Drug)
结局指标
主要结局
The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative
时间窗: Choices occur across a 40 minute session
The reinforcing effects of cocaine are determined using a reinforcement learning choice task. Subjects complete trials in which they could possibly receive the available cocaine dose or money. Reinforcing effects are measured for a fixed cocaine dose when three amounts of money are available as alternatives to cocaine. Each money value is tested in a separate session.
次要结局
未报告次要终点
研究者
Joshua A. Lile, Ph.D.
Professor of Behavioral Science
University of Kentucky