Protein Molecular Characteristics and Prognosis of Cervical Neuroendocrine Tumors
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 300
- 试验地点
- 9
- 主要终点
- mortality rate
研究概览
简要总结
The clinical diagnosis and treatment data of 300 cases of cervical neuroendocrine tumors were collected, including age, preoperative biopsy pathology results, postoperative histopathological results, TCT results, and colposcopy biopsy pathology results. At the same time, paraffin tissue specimens (remaining specimens after pathological diagnosis) from 100 cases of cervical neuroendocrine tumors from multiple centers across the country were collected to establish a cervical neuroendocrine tumor data follow-up database. Protein concentration and omics analysis were performed on the data results, to evaluate the molecular characteristics and prognosis of cervical neuroendocrine tumor proteins, and to preliminarily explore its clinical application value.
详细描述
- The clinical diagnosis and treatment data of 300 cases of cervical neuroendocrine tumors were used for prognostic analysis.
(1) The diagnosis and treatment information of cervical neuroendocrine carcinoma in multiple hospitals was collected, including clinical and medical data such as age, preoperative HPV genotyping, preoperative biopsy pathological results, postoperative histopathological results, FIGO staging, prognosis and survival information, and follow-up of patients.
- Protein and other omics analysis was performed on paraffin tissues of 100 cases of cervical neuroendocrine tumors Paraffin samples collected from 100 cases of cervical neuroendocrine tumors were identified, processed and segmtioned, and protein concentration and proteome were determined to establish the molecular characteristics and prognostic targets of cervical neuroendocrine tumors.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed with cervical neuroendocrine carcinoma by histopathology
- •Clinical data were complete
排除标准
- •Patients who are not being treated in our hospital
- •Patients with lack of follow-up data, unable to obtain survival information
- •Patients call to refuse to participate in this project
- •The quality of paraffin specimens can not meet the requirements of proteome concentration determination
结局指标
主要结局
mortality rate
时间窗: Among patients with cervical neuroendocrine carcinoma, the mortality rate within 3 years following surgery
3-year mortality rate for cervical neuroendocrine carcinoma
Disease-free survival
时间窗: Among patients with cervical neuroendocrine carcinoma, the disease-free survival within 3 years following surgery
3-year disease-free survival for cervical neuroendocrine carcinoma
次要结局
未报告次要终点