Validity of Fractional Exhaled Nitric Oxide and Impulse Oscillometry in Patients With Cough Variant Asthma
- Conditions
- Cough Variant Asthma
- Interventions
- Diagnostic Test: fractional exhaled nitric oxide(FeNO)Diagnostic Test: impulse oscillometry(IOS)
- Registration Number
- NCT03573284
- Lead Sponsor
- Zhujiang Hospital
- Brief Summary
The aim of the research is to evaluate the clinical value of fractional exhaled nitric oxide(FeNO) ,impulse oscillometry(IOS) and mid-expiratory flow (MEF) in patients with cough variant asthma.
- Detailed Description
The present study has the following objectives:
to evaluate the relationship between BHR and mid-expiratory flow, to assess the diagnostic accuracy of fractional exhaled nitric oxide，impulse oscillometry and mid-expiratory flow in CVA with special regard to its discriminating value between CVA and other causes of a chronic cough, to estimate prognostic value of BHR and fractional exhaled nitric oxide (FeNO) count in predicting response to asthma treatment.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 146
age 18-65 years old. Cough as the sole or predominant symptom lasting for at least 8 weeks, with no radiographic evidence of lung diseases.
treatment of any oral corticosteroid in the last 4 weeks, and respiratory tract infection within 8 weeks.
smoking (min. 6 months) had asthma or other lung diseases, including obliterative bronchiolitis, bronchiectasis,and cystic fibrosis.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Asthma group impulse oscillometry(IOS) Patients with chronic nonproductive cough for more than 8 weeks based on physician's opinion will be subjected to FeNO, impulse oscillometry(IOS) and pulmonary function. Receiver operating characteristic (ROC) curves to evaluate the clinical value of FeNO and small airways indices in CVA diagnosis. The optimal cutoff point for the level of FeNO and IOS is also determined. Asthma group fractional exhaled nitric oxide(FeNO) Patients with chronic nonproductive cough for more than 8 weeks based on physician's opinion will be subjected to FeNO, impulse oscillometry(IOS) and pulmonary function. Receiver operating characteristic (ROC) curves to evaluate the clinical value of FeNO and small airways indices in CVA diagnosis. The optimal cutoff point for the level of FeNO and IOS is also determined.
- Primary Outcome Measures
Name Time Method the value of fractional exhaled nitric oxide(FeNO) in patients with cough variant asthma at least 4 weeks of treatment FENO will be performed by using a hand-held portable machine (NIOX MINO, Aerocrine AB, Solna, Sweden) at a standard flow rate of 50 mL/s, in accordance with ATS/ERS recommendations.
the value of impulse oscillometry(IOS) in patients with cough variant asthma at least 4 weeks of treatment R5-R20（respiratory resistance）is measure by Jaeger MasterScreen Pulmonary
- Secondary Outcome Measures
Name Time Method the value of forced mid-expiratory flow (MMEF) in patients with cough variant asthma at least 4 weeks of treatment MMEF will be performed with a spirometer (Jaeger, Hoechberg, Germany) in accordance with the specifications and performance criteria recommended in the American Thoracic Society (ATS)/European Respiratory Society (ERS) Standardization of Spirometry
the value of BHR and fractional exhaled nitric oxide (FeNO) count in predicting response to asthma treatment at least 4 weeks of treatment MCH bronchial provocation tests will be performed with the Jaeger APS Pro system.Provocative dose causing a 20% fall in FEV1(PD20) will be recorded, and BHR is defined as present if PD20≤0.48 mg. FENO is measure by a hand-held portable machine(NIOX MINO, Aerocrine AB, Solna, Sweden)
the relationship between BHR and mid-expiratory flow at least 4 weeks of treatment BHR is measure by Jaeger APS Pro system.MMEF will be performed with a spirometer (Jaeger, Hoechberg, Germany)
Trial Locations
- Locations (1)
Huapeng Yu
🇨🇳Guangzhou, Guangdong, China