Prospective Pilot Study Evaluating the Prognostic Impact of a Neuro-vascular Examination Associated With Cerebral MRI in the Acute Phase of Infectious Endocarditis
Overview
- Phase
- Not Applicable
- Intervention
- Neurological assessment
- Conditions
- Endocarditis
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 29
- Locations
- 2
- Primary Endpoint
- Medical care modification
- Status
- Completed
- Last Updated
- yesterday
Overview
Brief Summary
Infectious endocarditis (IE) is a serious condition with an annual incidence of 3 to 10 per 100,000 people. Brain infarctions complicate approximately 20-40% of endocarditis.
Brain MRI can detect the presence of recent ischemic lesions and asymptomatic microbleeds. Preoperative brain imaging is part of the recommended assessment in the management of IEs, but the type of imaging and sequences are not codified and the impact of cerebral and vascular imaging findings on the therapeutic decision remains uncertain.
The level of evidence of the recommendations remains low, especially for complicated IEs of stroke. There is very little neurological clinical data on patients with IEs. Similarly, neurologists do not systematically participate in multidisciplinary meetings during the management of an IE. It therefore seems interesting to carry out a neurological cohort of this population and to evaluate what would be the contribution of vascular neurologists in the management of infectious endocarditis.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adult patients
- •Certain infectious endocarditis according to Dukes Criteria
- •Signed informed consent
Exclusion Criteria
- •Hospital admission due to neurovascular emergency
- •MRI contraindications
- •Pregnant or women of childbearing age who were not using contraception (oral diagnosis),
- •Patient without health coverage,
- •Patient under legal protection.
Arms & Interventions
Neurological cohort
All patients included in the study wil have a neurological examination
Intervention: Neurological assessment
Outcomes
Primary Outcomes
Medical care modification
Time Frame: at 3 months
Description of the medical care modification after neurological assessment, evaluated by the number of patients with modified medical care by the request for a new examination compared to the initially scheduled care.
Secondary Outcomes
- Evaluation of depressive anxiety disorders(at 3 months)
- Prognosis assessment(at 3 months)
- The description of the perioperative hemorrhagic risk(24 to 96 hours post-surgery)
- Evaluation of functional prognosis(at 3 months)
- Evaluation of the cognitive prognosis(at 3 months)
- The description of the preoperative neurological impairment(During initial hospitalization)