Evaluate the Effect of Omega-3 vs Soy Isoflavones in Postmenopausal Women With Moderate to Severe Vasomotor Symptoms
- Conditions
- Hot FlashesMenopause
- Interventions
- Dietary Supplement: Omega-3Dietary Supplement: Soy Isoflavones
- Registration Number
- NCT02195609
- Lead Sponsor
- Instituto Palacios
- Brief Summary
This study is aiming to evaluate changes in vasomotor symptoms in postmenopausal women treated for 4 months with Omega-3 vs Soy Isoflavones.
- Detailed Description
This is a non-inferiority study of Omega 3 versus Soy Isoflavones, being each patient its own control from the baseline.
In order to determine the difference observed in the evolution of intensity, frequency and the total number of hot flashes in 4 months in patients treated with Omega-3 vs Soy Isoflavones, is planned to include at least 100 patients, 50 per treatment arm.
It si estimated a standar deviation of 0.5%, and a 10% lost follow-up rate.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 75
- Ambulatory and can complete all study procedures, which are able to read, understand and sign an informed consent and willing to come to the center for study visits.
- Postmenopausal (≥ 1 year of amenorrhea) or 6 months or more of amenorrhea with follicle stimulating hormone (FSH) ≥ 40 IU / L.
- BMI ≥ 18 kg/m2 and ≤ 30 kg/m2
- Flushing of moderate to severe intensity.
- Women with surgical menopause.
- Treatment with hormone replacement therapy (HRT) in the 3 months prior to inclusion
- Uterine bleeding after menopause with undetermined cause in the 12 months prior to screening.
- Presence or history of malignancy in the past 5 years.
- Malabsorption syndrome.
- Hype or uncontrolled hypothyroidism.
- Dyslipidemia (LDL-cholesterol> 189 mg / dl or medical criteria) requiring an specific treatment of proven effectiveness.
- Chronic renal disease.
- Uncontrolled or untreated hypertension.
- Treatment with isoflavones, tibolone, Selective Estrogen Receptors Moderators (SERM´s) in the past 3 months prior to the testing selection period.
- Hormonal treatment with androgens, estrogens, progestins, alone or combined oral, transdermal, vaginal (including promestriene) or implant, in the last 3 months prior to testing selection period.
- Patients who receive or require treatment with antidepressants or anticonvulsants
- Patients with mental illness.
- History of noncompliance with taking medication.
- Suspected or abuse of alcohol or other drugs during the 12 months preceding the selection.
- Use of any experimental drug or device within 30 days prior to the selection.
- Any other condition or finding that a judgment of the investigator may jeopardise the tral conduct according to the protocol.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Omega-3 Omega-3 600 mg (EPA, DHA and Omega-3) twice a day Soy Isoflavones Soy Isoflavones 54.4mg oral twice a day
- Primary Outcome Measures
Name Time Method Evaluate the changes in vasomotor symptoms. 0 to 4 months To evaluate the changes in vasomotor symptoms in postmenopausal women measured by a hot flushes self-completed diary .
- Secondary Outcome Measures
Name Time Method Satisfaction with treatment at month 1 and 4 Treatment Satisfaction Questionnaire for Medication
General health status months 0, 1 and 4 General health status by Short-Form 36 (SF-36) questionnaire
Cardiovascular risk factors 0, 1 and 4 months abdominal circumference
Mood status 0, 1 and 4 months Hospital Anxiety and Depression Scale (HADS)
Rating memory status at 0, 1 and 4 months Alteration of the memory test (T@M)
Trial Locations
- Locations (1)
Instituto Palacios
🇪🇸Madrid, Spain