Blood Nitrate/Nitrite Concentrations Following Acute Ingestion of Resync in Men and Women
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Memphis
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Change in systolic blood pressure from daily baseline with 15g Resync
Study Overview
Brief Summary
This study evaluates acute ingestion of the dietary supplement Resync on blood nitrate/nitrite concentrations in a sample of men and women. This will be a crossover trial in which participants take all 4 conditions: 1) 7.5g Resync, 2) 15g Resync, 3) 20g Resync+collagen, 4) placebo.
Detailed Description
The product known as Resync contains a blend of nitrate-rich foods including beetroot, red spinach, turmeric, ginger root, and aronia berry extracts. Resync is sold commercially and marketed as an ergogenic aid and/or exercise recovery aid. Manufacturers of Resync recommend users take this product 60-90 minutes before an athletic event or 30-90 minutes after exercise. Resync bases these claims on prior studies investigating the individual ingredients' abilities to increase blood nitrate/nitrite levels; however, there are no clinical trials on the finished product itself.
The purpose of this pilot study is to determine the impact of acute, single ingestion of Resync products on blood nitrate/nitrite concentration in a sample of men and women. This will be a crossover trial in which participants take all 4 conditions: 1) 7.5g Resync, 2) 15g Resync, 3) 20g Resync+collagen, 4) placebo.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Single (Participant)
Masking Description
Single-Blind
Eligibility Criteria
- Ages
- 18 Years to 50 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •BMI 18 - 29.9 kg/m2
- •Non-smoker
- •Non-vegan
- •Not using nitrate-based dietary supplements
Exclusion Criteria
- •Diagnosed history of diabetes
- •Diagnosed history of cardiovascular disease
- •Diagnosed history of neurological disease
- •Pregnant females
Arms & Interventions
Placebo-controlled Arm
Placebo - 12oz water with food coloring
Intervention: Placebo (Other)
1 serving Resync Arm
12oz water + 7.5g Resync
Intervention: Resync (Dietary Supplement)
2 servings Resync Arm
12oz water + 15g Resync
Intervention: Resync (Dietary Supplement)
1 servings Resync+Collagen Arm
12oz water + 17g collagen + 2g Resync + 1g Carbohydrates
Intervention: Resync + Collagen (Dietary Supplement)
Outcomes
Primary Outcomes
Change in systolic blood pressure from daily baseline with 15g Resync
Time Frame: 75-minutes post supplement ingestion
We will determine the change in daily systolic blood pressure with supplementation from the daily baseline systolic blood pressure with 2 servings (15g) of Resync. Resync powder will be mixed with 12oz of water.
Change in systolic blood pressure from daily baseline with 20g Resync+Collagen
Time Frame: 75-minutes post supplement ingestion
We will determine the change in daily systolic blood pressure with supplementation from the daily baseline systolic blood pressure with 1 serving (20g) of Resync+Collagen. This blend contains approximately 17g of collagen, 2 g of Resync, and 1g carbohydrates. Resync+Collagen powder will be mixed with 12oz of water.
Change in blood nitrate+nitrite levels from daily baseline with 7.5g Resync
Time Frame: 75-minutes post supplement ingestion
We will determine the change in daily blood nitrate+nitrite from the daily baseline blood nitrate+nitrite with 1 serving (7.5g) of Resync. Resync powder will be mixed with 12oz of water.
Change in blood nitrate+nitrite levels from daily baseline with 15g Resync
Time Frame: 75-minutes post supplement ingestion
We will determine the change in daily blood nitrate+nitrite from the daily baseline blood nitrate+nitrite with 2 servings (15g) of Resync. Resync powder will be mixed with 12oz of water.
Change in blood nitrate+nitrite levels from daily baseline with 20g Resync+Collagen
Time Frame: 75-minutes post supplement ingestion
We will determine the change in daily blood nitrate+nitrite from the daily baseline blood nitrate+nitrite with 1 serving (20g) of Resync+Collagen. This blend contains approximately 17g of collagen, 2 g of Resync, and 1g carbohydrates. Resync+Collagen powder will be mixed with 12oz of water.
Change in blood nitrate+nitrite levels from daily baseline with placebo.
Time Frame: 75-minutes post supplement ingestion
We will determine the change in daily blood nitrate+nitrite from the daily baseline blood nitrate+nitrite with 12oz of food colored water. A red food dye will be used to match coloring of supplements.
Change in systolic blood pressure from daily baseline with 7.5g Resync
Time Frame: 75-minutes post supplement ingestion
We will determine the change in daily systolic blood pressure with supplementation from the daily baseline systolic blood pressure with 1 serving (7.5g) of Resync. Resync powder will be mixed with 12oz of water.
Change in diastolic blood pressure from daily baseline with 15g Resync
Time Frame: 75-minutes post supplement ingestion
We will determine the change in daily diastolic blood pressure with supplementation from the daily baseline diastolic blood pressure with 2 servings (15g) of Resync. Resync powder will be mixed with 12oz of water.
Change in diastolic blood pressure from daily baseline with 7.5g Resync
Time Frame: 75-minutes post supplement ingestion
We will determine the change in daily diastolic blood pressure with supplementation from the daily baseline diastolic blood pressure with 1 serving (7.5g) of Resync. Resync powder will be mixed with 12oz of water.
Change in systolic blood pressure from daily baseline with placebo
Time Frame: 75-minutes post supplement ingestion
We will determine the change in daily systolic blood pressure with supplementation from the daily baseline systolic blood pressure with 12oz of food colored water. A red food dye will be used to match coloring of supplements.
Change in diastolic blood pressure from daily baseline with placebo
Time Frame: 75-minutes post supplement ingestion
We will determine the change in daily diastolic blood pressure with supplementation from the daily baseline diastolic blood pressure with 12oz of food colored water. A red food dye will be used to match coloring of supplements.
Change in diastolic blood pressure from daily baseline with 20g Resync+Collagen
Time Frame: 75-minutes post supplement ingestion
We will determine the change in daily diastolic blood pressure with supplementation from the daily baseline diastolic blood pressure with 1 serving (20g) of Resync+Collagen. This blend contains approximately 17g of collagen, 2 g of Resync, and 1g carbohydrates. Resync+Collagen powder will be mixed with 12oz of water.
Secondary Outcomes
- Change in heart rate from daily baseline with 15g Resync(75-minutes post supplement ingestion)
- Change in heart rate from daily baseline with placebo(75-minutes post supplement ingestion)
- Change in heart rate from daily baseline with 7.5g Resync(75-minutes post supplement ingestion)
- Change in heart rate from daily baseline with 20g Resync+Collagen(75-minutes post supplement ingestion)
Investigators
Richard Bloomer
Dean of School of Health Studies
University of Memphis