High-Intensity Training Following Lung Transplantation

Not Applicable

Completed

• Conditions: Lung Transplant; Exercise Training
• Interventions: Behavioral: High-intensity training

• Registration Number: NCT03155074
• Lead Sponsor: Oslo University Hospital

Brief Summary

The HILT study is a prospective, single-blinded, randomized controlled trial comparing a high-intensity exercise training intervention with usual care among adult lung transplant recipients. Patients randomized to the training intervention arm will undergo individually tailored high-intensity exercise training (80-95% of maximum heart rate) three hours per week for 20 weeks. Training will be conducted at local fitness centers on a one-on-one basis.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-05-10
• Study First Submitted QC: 2017-05-15
• Study First Posted: 2017-05-16
• Study Start: 2017-08-22
• Primary Completion: 2019-01-31
• Study Completion: 2019-01-31
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-27
• Last Update Posted: 2023-11-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

• Stable medical condition in the opinion of the enrolling investigator
• Able and willing to give informed consent

Exclusion Criteria

• Expected survival less than 12 months
• Unable to complete a maximal exercise test on a treadmill until exhaustion
• Language barrier that interferes with data collection

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
High-Intensity Training	High-intensity training	-

Primary Outcome Measures

Name	Time	Method
Change in peak oxygen uptake	0-20 weeks	Measured by cardiopulmonary exercise test

Secondary Outcome Measures

Name	Time	Method
Change in total body composition (fat, muscle and bone mass)	0-20 weeks	Measured by dual-energy x-ray absorptiometry (DEXA)
Change in upper body strength	0-20 weeks	Measured by maximum breast press
Change in forced expiratory volume in one second (FEV1)	0-20 weeks	Measured by spirometry
Change in leg strength	0-20 weeks	Measured by maximum leg press
Change submaximal exercise capacity	0-20 weeks	Measured by 6-minute walk distance
Change in hand strength	0-20 weeks	Measured by grip strength dynamometer
Change in health-related quality of life	0-20 weeks	Measured by Short Form 36 (SF-36)

Trial Locations

Locations (1)

Oslo University Hospital; 🇳🇴 Oslo, Norway