Effects of Atorvastatin on Hepatitis B vaccination efficacy
Not Applicable
- Conditions
- Immunization against Viral Hepatitis B.Need for immunization against Viral Hepatitis
- Registration Number
- IRCT201109147556N1
- Lead Sponsor
- Baqiyatallah University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 52
Inclusion Criteria
HbsAb<10 after 3 dose hepatitis B vaccination- negative HBsAb- negative HBcAb- negative HBsAb.
?Exclusion criteria: positive serologic evidence of Hepatitis B infection- chronic use of Atorvastatin- immunosuppressive illness
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method HBsAb level in serum. Timepoint: Before Atorvastatine use and 1 month after vaccination. Method of measurement: Quantitative ELIZA.;IL-4 , IL17 , TGFB , IFN-gamma. Timepoint: After WBC culture and exposure with vaccine in vitro. Method of measurement: Polymerase Chain Reaction (PCR).
- Secondary Outcome Measures
Name Time Method Immunization against viral hepatitis B. Timepoint: Befor and 1 month after vaccination. Method of measurement: Quantitative ELIZA.