Early Life Origins of Pediatric and Adult Diseases: Boston Birth Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 24,000
- 试验地点
- 2
- 主要终点
- Birth outcomes - birthweight
研究概览
简要总结
Early life exposures may lead to adverse effects on health in later life. The Boston birth Cohort study is designed to study a broad array of early life factors and their effects on maternal and child health outcomes across the life course.
详细描述
Any woman admitted to the Labor and Delivery floor at the Boston Medical Center (BMC) who delivers a singleton live infant and meets our case (gestational age <37 weeks or birthweight <2,500 grams) or control (full term birth with birthweight >2,500 grams) criteria will be eligible.
Postnatal follow-up of enrolled mother-child pair is conducted from birth to age 21 years.
The Boston Birth Cohort has high-quality biospecimen collection, and comprehensive epidemiological, clinical, and environmental exposure data via standardized questionnaire interview, measurements, and review of the electronic medical records.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 0 Years 至 50 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Mothers who deliver singleton live births at Boston Medical Center are eligible for the study.
排除标准
- •pregnancies that are a result of in vitro fertilization or that involve multiple gestations, fetal chromosomal abnormalities or major birth defects.
结局指标
主要结局
Birth outcomes - birthweight
时间窗: At birth
Birth outcomes are examined - birthweight.
Child health outcomes
时间窗: From birth to 21 years
Multiple child health outcomes are examined including food allergy, asthma, child's overweight or obesity, blood pressure, and child neuro-developmental outcomes.
Pregnancy complications
时间窗: At birth
Multiple pregnancy complications are examined including gestational diabetes, hypertensive disorders of pregnancy.
Birth outcomes - preterm birth
时间窗: At birth
Birth outcomes are examined - preterm birth.
Maternal health outcomes
时间窗: After delivery to 21 years
Multiple maternal health outcomes are measured including blood pressure, weight, height, physician diagnosis.
Participants with Pregnancy complications - including hypertensive disorders and gestational diabetes
时间窗: At birth
hypertensive disorders during pregnancy, gestational diabetes
Birth outcomes - number of participants with preterm births
时间窗: At birth
Birth outcomes are examined - preterm birth.
Birth outcomes - birth weight in grams (g)
时间窗: At birth
Birth outcomes are examined - birth weight (g)
Child health outcomes - number of participants overweight or obese
时间窗: From birth to 21 years
overweight or obesity
Maternal health outcomes - number of participants with maternal diabetes
时间窗: After delivery to 21 years
maternal diabetes
child health outcome - systolic and diastolic blood pressure
时间窗: from birth to 21 years
blood pressure (mmHg)
child health outcome - participants with neuro-developmental disorders including autism and ADHD
时间窗: from birth to 21 years
neuro-developmental disorders including autism and ADHD
child health outcome - number of participants with asthma
时间窗: from birth to 21 years
asthma
次要结局
未报告次要终点