Boston Birth Cohort Study

Recruiting

• Conditions: Child Health; Pregnancy Complications; Birth Outcome, Adverse; Maternal Health

• Registration Number: NCT03228875
• Lead Sponsor: Johns Hopkins Bloomberg School of Public Health

Brief Summary

Early life exposures may lead to adverse effects on health in later life. The Boston birth Cohort study is designed to study a broad array of early life factors and their effects on maternal and child health outcomes.

Detailed Description

Any woman admitted to the Labor and Delivery floor at the Boston Medical Center (BMC) who delivers a singleton live infant and meets our case (gestational age \<37 weeks or birthweight \<2,500 grams) or control (full term birth with birthweight \>2,500 grams) criteria will be eligible.

Postnatal follow-up of enrolled mother-child pair is conducted from birth to age 21 years.

The Boston Birth Cohort has high-quality biospecimen collection, and comprehensive epidemiological, clinical, and environmental exposure data via standardized questionnaire interview, measurements, and review of the electronic medical records.

Study Timeline

• Study Start: 1998-10
• Study First Submitted: 2017-07-20
• Study First Submitted QC: 2017-07-21
• Study First Posted: 2017-07-25
• Status Verified: 2023-09
• Last Update Submitted: 2023-09-11
• Last Update Posted: 2023-09-13
• Primary Completion: 2028-12
• Study Completion: 2028-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 24000

Inclusion Criteria

• Mothers who deliver singleton live births at Boston Medical Center are eligible for the study.

Exclusion Criteria

• pregnancies that are a result of in vitro fertilization or that involve multiple gestations, fetal chromosomal abnormalities or major birth defects.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pregnancy complications	At birth	Multiple pregnancy complications are examined including gestational diabetes, hypertensive disorders of pregnancy.
Birth outcomes - preterm birth	At birth	Birth outcomes are examined - preterm birth.
Child health outcomes	From birth to 21 years	Multiple child health outcomes are examined including food allergy, asthma, child's overweight or obesity, blood pressure, and child neuro-developmental outcomes.
Birth outcomes - birthweight	At birth	Birth outcomes are examined - birthweight.
Maternal health outcomes	After delivery to 21 years	Multiple maternal health outcomes are measured including blood pressure, weight, height, physician diagnosis.

Trial Locations

Locations (1)

Boston Medical Center; 🇺🇸 Boston, Massachusetts, United States