Biomarker-s of Abusive Head Trauma by Proteomics

Not yet recruiting

• Conditions: Abuse, Child; Protein Disorder, Blood
• Interventions: Other: Blood test

• Registration Number: NCT05626465
• Lead Sponsor: University Hospital, Geneva

Brief Summary

The aim of our study is to highlight biomarker-s of Abusive Head Trauma by proteomics analyses on the serum of child victims of abuse.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-11-15
• Study First Submitted QC: 2022-11-15
• Study First Posted: 2022-11-23
• Status Verified: 2023-01
• Last Update Submitted: 2023-01-11
• Last Update Posted: 2023-01-13
• Study Start: 2023-02
• Primary Completion: 2028-02
• Study Completion: 2028-02

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 174

Inclusion Criteria

• Age : 0-2 y.o
• Medical consultation for malaise, seizure (without fever), loss of consciousness, traumatic bain injury, or cranioplasty
• Blood test during medical care
• Accepted informed consent

Exclusion Criteria

• Refused informed consent
• For control groups : medical history of child abuse
• For AHT group : rare metabolic disease (Menkes, etc..)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Abusive Head Trauma (AHT)	Blood test	-
Accidental traumatic brain injury	Blood test	-
Cranioplasty	Blood test	-
Infant malaise without AHT	Blood test	-

Primary Outcome Measures

Name	Time	Method
Highlight novel biomarker-s of AHT	Hospital admission to discharge (up to 3 days)	Proteomic analyses will be made on serum of infant victim of AHT. Results will be compare with control groups (traumatic brain injury, cranioplasty, malaise).

Trial Locations

Locations (2)

Ginhoux Thiphanie; 🇫🇷 Lyon, Rhône, France

Wiskott Kim; 🇨🇭 Geneva, Switzerland