NCT00553709
Terminated
Phase 2
The Role of Transcutaneous Nicotine in the Prevention of Postoperative Nausea and Vomiting in Non-smokers
Overview
- Phase
- Phase 2
- Intervention
- Nicotine
- Conditions
- Postoperative Nausea and Vomiting
- Sponsor
- University Hospital, Geneva
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Prevention of PONV
- Status
- Terminated
- Last Updated
- 16 years ago
Overview
Brief Summary
The purpose of this study is to determine whether nicotine is effective in the prevention of nausea and vomiting in non-smokers undergoing surgery
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adults (18-80 years)
- •ASA I-II, non-smokers (or ex-smokers who have not been smoking for more than 2 years)
- •Undergoing elective surgery (ENT, abdominal, urological, gynaecological); and
- •Consenting to take part in the study will be included.
Exclusion Criteria
- •Smokers (cigarette, pipe, cigar)
- •Patients undergoing nicotine replacement therapy
- •Prolonged postoperative intubation
- •Postoperative nasogastric tube
Arms & Interventions
Nicotine patch
Nicotinell® Patch 10 cm2, containing 17.5 mg of nicotine, with an average delivery rate of 7 mg of nicotine per 24 hours (= TTS 10)
Intervention: Nicotine
Placebo patch
Placebo patch 10 cm2
Intervention: Nicotine
Outcomes
Primary Outcomes
Prevention of PONV
Time Frame: 48 hours postoperatively
Secondary Outcomes
- Adverse effects that may be related to the nicotine patch, for instance, local skin reaction.(48 hours postoperatively)
Study Sites (1)
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