Prognosis of Low-grade Endometrial Stromal Sarcoma

Recruiting

• Conditions: Survival Outcomes; Recurrence; Hormone Therapy; Adjuvant Therapy; Low Grade Endometrial Stromal Sarcoma of Uterus (Diagnosis); Fertility-sparing Surgery; Fertility Outcomes

• Registration Number: NCT05310318
• Lead Sponsor: Lei Li

Brief Summary

This study is to investigate the survival outcomes and fertility outcomes in patients with uterine low-grade endometrial stromal sarcoma (LGESS) treated in Peking Union Medical College Hospital. All primary and recurrent LGESS patients will be enrolled. The study will collect retrospectively data consisting of epidemiological characteristics, surgical, medical treatment and adjuvant therapy. Details about recurrence, mortality, pregnancy and obstetrical outcomes are also followed as primary endpoints. Fertility-sparing procedures, including uterine-sparing and ovary-sparing surgeries will be recorded specifically.

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-03
• Study Start: 2022-03-26
• Study First Submitted: 2022-03-26
• Study First Submitted QC: 2022-03-26
• Last Update Submitted: 2022-03-26
• Study First Posted: 2022-04-04
• Last Update Posted: 2022-04-04
• Primary Completion: 2024-03-26
• Study Completion: 2025-03-26

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Aged 18 years or older
• Confirmed of LGESS
• Acceptance of surgical treatment for LGESS
• With detailed follow-up outcomes

Exclusion Criteria

• Not meeting all of the inclusion criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Progression-free survival	One year	Progression-free survival after surgery
Pregnancy rate	One year	Pregnancy rate after surgery in patients with fertility-sparing patients
Overall survival	One year	Overall survival after surgery

Secondary Outcome Measures

Name	Time	Method
Full-term pregnancy rate	One year	Full-term pregnancy rate after surgery in patients with fertility-sparing patients
Miscarriage rate	One year	Miscarriage rate after surgery in patients with fertility-sparing patients

Trial Locations

Locations (1)

Lei Li; 🇨🇳 Beijing, Beijing, China